- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-LZTS1/ F37/ FEZ1 monoclonal antibody
Anti-LZTS1/ F37/ FEZ1 antibody for FACS & in-vivo assay
Go to LZTS1/LZTS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2189-Ab-1/ GM-Tg-hg-MP2189-Ab-2 | Anti-Human LZTS1 monoclonal antibody | Human |
| GM-Tg-rg-MP2189-Ab-1/ GM-Tg-rg-MP2189-Ab-2 | Anti-Rat LZTS1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2189-Ab-1/ GM-Tg-mg-MP2189-Ab-2 | Anti-Mouse LZTS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2189-Ab-1/ GM-Tg-cynog-MP2189-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LZTS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2189-Ab-1/ GM-Tg-felg-MP2189-Ab-2 | Anti-Feline LZTS1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2189-Ab-1/ GM-Tg-cang-MP2189-Ab-2 | Anti-Canine LZTS1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2189-Ab-1/ GM-Tg-bovg-MP2189-Ab-2 | Anti-Bovine LZTS1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2189-Ab-1/ GM-Tg-equg-MP2189-Ab-2 | Anti-Equine LZTS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2189-Ab-1/ GM-Tg-hg-MP2189-Ab-2; GM-Tg-rg-MP2189-Ab-1/ GM-Tg-rg-MP2189-Ab-2; GM-Tg-mg-MP2189-Ab-1/ GM-Tg-mg-MP2189-Ab-2; GM-Tg-cynog-MP2189-Ab-1/ GM-Tg-cynog-MP2189-Ab-2; GM-Tg-felg-MP2189-Ab-1/ GM-Tg-felg-MP2189-Ab-2; GM-Tg-cang-MP2189-Ab-1/ GM-Tg-cang-MP2189-Ab-2; GM-Tg-bovg-MP2189-Ab-1/ GM-Tg-bovg-MP2189-Ab-2; GM-Tg-equg-MP2189-Ab-1/ GM-Tg-equg-MP2189-Ab-2 |
| Products Name | Anti-LZTS1 monoclonal antibody |
| Format | mab |
| Target Name | LZTS1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LZTS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LZTS1/ F37/ FEZ1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002865 | human LZTS1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002865 | human LZTS1 Lentivirus particle |
| ORF Viral Vector | pGMLPm005069 | mouse Lzts1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005069 | mouse Lzts1 Lentivirus particle |
Target information
| Target ID | GM-MP2189 |
| Target Name | LZTS1 |
| Gene ID | 11178,211134,266711,705724,486136,101092354,539634,100053630 |
| Gene Symbol and Synonyms | F37,FEZ1,LZTS1,PSD-Zip70,Psdzip70 |
| Uniprot Accession | Q9Y250,Q8CFC9 |
| Uniprot Entry Name | LZTS1_HUMAN,LZTS1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000061337 |
| Target Classification | N/A |
The target: LZTS1, gene name: LZTS1, also named as F37, FEZ1. This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
