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Anti-M3K12/ MAP3K12/ DLK monoclonal antibody
Anti-M3K12/ MAP3K12/ DLK antibody for FACS & in-vivo assay
Go to MAP3K12/MAP3K12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2193-Ab-1/ GM-Tg-hg-MP2193-Ab-2 | Anti-Human MAP3K12 monoclonal antibody | Human |
| GM-Tg-rg-MP2193-Ab-1/ GM-Tg-rg-MP2193-Ab-2 | Anti-Rat MAP3K12 monoclonal antibody | Rat |
| GM-Tg-mg-MP2193-Ab-1/ GM-Tg-mg-MP2193-Ab-2 | Anti-Mouse MAP3K12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2193-Ab-1/ GM-Tg-cynog-MP2193-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAP3K12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2193-Ab-1/ GM-Tg-felg-MP2193-Ab-2 | Anti-Feline MAP3K12 monoclonal antibody | Feline |
| GM-Tg-cang-MP2193-Ab-1/ GM-Tg-cang-MP2193-Ab-2 | Anti-Canine MAP3K12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2193-Ab-1/ GM-Tg-bovg-MP2193-Ab-2 | Anti-Bovine MAP3K12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2193-Ab-1/ GM-Tg-equg-MP2193-Ab-2 | Anti-Equine MAP3K12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2193-Ab-1/ GM-Tg-hg-MP2193-Ab-2; GM-Tg-rg-MP2193-Ab-1/ GM-Tg-rg-MP2193-Ab-2; GM-Tg-mg-MP2193-Ab-1/ GM-Tg-mg-MP2193-Ab-2; GM-Tg-cynog-MP2193-Ab-1/ GM-Tg-cynog-MP2193-Ab-2; GM-Tg-felg-MP2193-Ab-1/ GM-Tg-felg-MP2193-Ab-2; GM-Tg-cang-MP2193-Ab-1/ GM-Tg-cang-MP2193-Ab-2; GM-Tg-bovg-MP2193-Ab-1/ GM-Tg-bovg-MP2193-Ab-2; GM-Tg-equg-MP2193-Ab-1/ GM-Tg-equg-MP2193-Ab-2 |
| Products Name | Anti-MAP3K12 monoclonal antibody |
| Format | mab |
| Target Name | MAP3K12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MAP3K12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species M3K12/ MAP3K12/ DLK VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2193 |
| Target Name | MAP3K12 |
| Gene ID | 7786,26404,25579,703059,607170,101087164,505427,100064002 |
| Gene Symbol and Synonyms | DLK,HP09298,MAP3K12,MEKK12,MUK,PK,ZPK,ZPKP1 |
| Uniprot Accession | Q12852,Q63796 |
| Uniprot Entry Name | M3K12_HUMAN,M3K12_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000139625 |
| Target Classification | Kinase |
The target: MAP3K12, gene name: MAP3K12, also named as DLK, MEKK12, MUK, ZPK, ZPKP1. This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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