Anti-MISP/ C19orf211 monoclonal antibody

Anti-MISP/ C19orf211 antibody for FACS & in-vivo assay

Target products collectionGo to MISP/MISP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2199-Ab-1/ GM-Tg-hg-MP2199-Ab-2Anti-Human MISP monoclonal antibodyHuman
GM-Tg-rg-MP2199-Ab-1/ GM-Tg-rg-MP2199-Ab-2Anti-Rat MISP monoclonal antibodyRat
GM-Tg-mg-MP2199-Ab-1/ GM-Tg-mg-MP2199-Ab-2Anti-Mouse MISP monoclonal antibodyMouse
GM-Tg-cynog-MP2199-Ab-1/ GM-Tg-cynog-MP2199-Ab-2Anti-Cynomolgus/ Rhesus macaque MISP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2199-Ab-1/ GM-Tg-felg-MP2199-Ab-2Anti-Feline MISP monoclonal antibodyFeline
GM-Tg-cang-MP2199-Ab-1/ GM-Tg-cang-MP2199-Ab-2Anti-Canine MISP monoclonal antibodyCanine
GM-Tg-bovg-MP2199-Ab-1/ GM-Tg-bovg-MP2199-Ab-2Anti-Bovine MISP monoclonal antibodyBovine
GM-Tg-equg-MP2199-Ab-1/ GM-Tg-equg-MP2199-Ab-2Anti-Equine MISP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2199-Ab-1/ GM-Tg-hg-MP2199-Ab-2; GM-Tg-rg-MP2199-Ab-1/ GM-Tg-rg-MP2199-Ab-2;
GM-Tg-mg-MP2199-Ab-1/ GM-Tg-mg-MP2199-Ab-2; GM-Tg-cynog-MP2199-Ab-1/ GM-Tg-cynog-MP2199-Ab-2;
GM-Tg-felg-MP2199-Ab-1/ GM-Tg-felg-MP2199-Ab-2; GM-Tg-cang-MP2199-Ab-1/ GM-Tg-cang-MP2199-Ab-2;
GM-Tg-bovg-MP2199-Ab-1/ GM-Tg-bovg-MP2199-Ab-2; GM-Tg-equg-MP2199-Ab-1/ GM-Tg-equg-MP2199-Ab-2
Products NameAnti-MISP monoclonal antibody
Formatmab
Target NameMISP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MISP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MISP/ C19orf211 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2199
    Target NameMISP
    Gene ID126353,78906,500797,703197,100855921,101092496,505316,102147542
    Gene Symbol and Synonyms9130017N09Rik,C19orf21,C7H19orf21,CA2H19orf21,MISP,MISP1
    Uniprot AccessionQ8IVT2
    Uniprot Entry NameMISP_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000099812
    Target ClassificationN/A

    The target: MISP, gene name: MISP, also named as C19orf211, MISP. The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.