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Anti-EM55/ MPP1/ AAG12 monoclonal antibody
Anti-EM55/ MPP1/ AAG12 antibody for FACS & in-vivo assay
Go to MPP1/MPP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2201-Ab-1/ GM-Tg-hg-MP2201-Ab-2 | Anti-Human MPP1 monoclonal antibody | Human |
| GM-Tg-rg-MP2201-Ab-1/ GM-Tg-rg-MP2201-Ab-2 | Anti-Rat MPP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2201-Ab-1/ GM-Tg-mg-MP2201-Ab-2 | Anti-Mouse MPP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2201-Ab-1/ GM-Tg-cynog-MP2201-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MPP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2201-Ab-1/ GM-Tg-felg-MP2201-Ab-2 | Anti-Feline MPP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2201-Ab-1/ GM-Tg-cang-MP2201-Ab-2 | Anti-Canine MPP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2201-Ab-1/ GM-Tg-bovg-MP2201-Ab-2 | Anti-Bovine MPP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2201-Ab-1/ GM-Tg-equg-MP2201-Ab-2 | Anti-Equine MPP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2201-Ab-1/ GM-Tg-hg-MP2201-Ab-2; GM-Tg-rg-MP2201-Ab-1/ GM-Tg-rg-MP2201-Ab-2; GM-Tg-mg-MP2201-Ab-1/ GM-Tg-mg-MP2201-Ab-2; GM-Tg-cynog-MP2201-Ab-1/ GM-Tg-cynog-MP2201-Ab-2; GM-Tg-felg-MP2201-Ab-1/ GM-Tg-felg-MP2201-Ab-2; GM-Tg-cang-MP2201-Ab-1/ GM-Tg-cang-MP2201-Ab-2; GM-Tg-bovg-MP2201-Ab-1/ GM-Tg-bovg-MP2201-Ab-2; GM-Tg-equg-MP2201-Ab-1/ GM-Tg-equg-MP2201-Ab-2 |
| Products Name | Anti-MPP1 monoclonal antibody |
| Format | mab |
| Target Name | MPP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MPP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EM55/ MPP1/ AAG12 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000626 | human MPP1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000626 | human MPP1 Lentivirus particle |
| ORF Viral Vector | pGMLPm003841 | mouse Mpp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003841 | mouse Mpp1 Lentivirus particle |
Target information
| Target ID | GM-MP2201 |
| Target Name | MPP1 |
| Gene ID | 4354,17524,702092,612626,101092503,510998,100063094 |
| Gene Symbol and Synonyms | 55kDa,AAG12,C130070C03Rik,DXS552E,EMP55,MPP1,MRG1,p55,PEMP |
| Uniprot Accession | Q00013,Q17QN6 |
| Uniprot Entry Name | EM55_HUMAN,EM55_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130830 |
| Target Classification | N/A |
The target: MPP1, gene name: MPP1, also named as AAG12, DXS552E, EMP55, MRG1, PEMP. This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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