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Anti-RM42/ MRPL42/ HSPC204 monoclonal antibody
Anti-RM42/ MRPL42/ HSPC204 antibody for FACS & in-vivo assay
Go to MRPL42/MRPL42 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2204-Ab-1/ GM-Tg-hg-MP2204-Ab-2 | Anti-Human MRPL42 monoclonal antibody | Human |
| GM-Tg-rg-MP2204-Ab-1/ GM-Tg-rg-MP2204-Ab-2 | Anti-Rat MRPL42 monoclonal antibody | Rat |
| GM-Tg-mg-MP2204-Ab-1/ GM-Tg-mg-MP2204-Ab-2 | Anti-Mouse MRPL42 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2204-Ab-1/ GM-Tg-cynog-MP2204-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MRPL42 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2204-Ab-1/ GM-Tg-felg-MP2204-Ab-2 | Anti-Feline MRPL42 monoclonal antibody | Feline |
| GM-Tg-cang-MP2204-Ab-1/ GM-Tg-cang-MP2204-Ab-2 | Anti-Canine MRPL42 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2204-Ab-1/ GM-Tg-bovg-MP2204-Ab-2 | Anti-Bovine MRPL42 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2204-Ab-1/ GM-Tg-equg-MP2204-Ab-2 | Anti-Equine MRPL42 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2204-Ab-1/ GM-Tg-hg-MP2204-Ab-2; GM-Tg-rg-MP2204-Ab-1/ GM-Tg-rg-MP2204-Ab-2; GM-Tg-mg-MP2204-Ab-1/ GM-Tg-mg-MP2204-Ab-2; GM-Tg-cynog-MP2204-Ab-1/ GM-Tg-cynog-MP2204-Ab-2; GM-Tg-felg-MP2204-Ab-1/ GM-Tg-felg-MP2204-Ab-2; GM-Tg-cang-MP2204-Ab-1/ GM-Tg-cang-MP2204-Ab-2; GM-Tg-bovg-MP2204-Ab-1/ GM-Tg-bovg-MP2204-Ab-2; GM-Tg-equg-MP2204-Ab-1/ GM-Tg-equg-MP2204-Ab-2 |
| Products Name | Anti-MRPL42 monoclonal antibody |
| Format | mab |
| Target Name | MRPL42 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MRPL42 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RM42/ MRPL42/ HSPC204 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2204 |
| Target Name | MRPL42 |
| Gene ID | 28977,67270,299743,715676,475426,102900691,614148,100629608 |
| Gene Symbol and Synonyms | 2700009F22Rik,2900055D03Rik,D10Ertd322e,HSPC204,L31MT,L42MT,MRP-L31,MRP-L42,MRP-S32,MRPL31,MRPL42,MRPS32,PTD007,RPML31,S32MT |
| Uniprot Accession | Q9Y6G3,P82927 |
| Uniprot Entry Name | RM42_HUMAN,RM42_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000198015 |
| Target Classification | N/A |
The target: MRPL42, gene name: MRPL42, also named as HSPC204, L31MT, L42MT, MRP-L31, MRP-L42, MRP-S32, MRPL31, MRPS32, PTD007, RPML31, S32MT. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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