Anti-MUC20/ MUC-20 monoclonal antibody

Anti-MUC20/ MUC-20 antibody for FACS & in-vivo assay

Target products collectionGo to MUC20/MUC20 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2207-Ab-1/ GM-Tg-hg-MP2207-Ab-2Anti-Human MUC20 monoclonal antibodyHuman
GM-Tg-rg-MP2207-Ab-1/ GM-Tg-rg-MP2207-Ab-2Anti-Rat MUC20 monoclonal antibodyRat
GM-Tg-mg-MP2207-Ab-1/ GM-Tg-mg-MP2207-Ab-2Anti-Mouse MUC20 monoclonal antibodyMouse
GM-Tg-cynog-MP2207-Ab-1/ GM-Tg-cynog-MP2207-Ab-2Anti-Cynomolgus/ Rhesus macaque MUC20 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2207-Ab-1/ GM-Tg-felg-MP2207-Ab-2Anti-Feline MUC20 monoclonal antibodyFeline
GM-Tg-cang-MP2207-Ab-1/ GM-Tg-cang-MP2207-Ab-2Anti-Canine MUC20 monoclonal antibodyCanine
GM-Tg-bovg-MP2207-Ab-1/ GM-Tg-bovg-MP2207-Ab-2Anti-Bovine MUC20 monoclonal antibodyBovine
GM-Tg-equg-MP2207-Ab-1/ GM-Tg-equg-MP2207-Ab-2Anti-Equine MUC20 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2207-Ab-1/ GM-Tg-hg-MP2207-Ab-2; GM-Tg-rg-MP2207-Ab-1/ GM-Tg-rg-MP2207-Ab-2;
GM-Tg-mg-MP2207-Ab-1/ GM-Tg-mg-MP2207-Ab-2; GM-Tg-cynog-MP2207-Ab-1/ GM-Tg-cynog-MP2207-Ab-2;
GM-Tg-felg-MP2207-Ab-1/ GM-Tg-felg-MP2207-Ab-2; GM-Tg-cang-MP2207-Ab-1/ GM-Tg-cang-MP2207-Ab-2;
GM-Tg-bovg-MP2207-Ab-1/ GM-Tg-bovg-MP2207-Ab-2; GM-Tg-equg-MP2207-Ab-1/ GM-Tg-equg-MP2207-Ab-2
Products NameAnti-MUC20 monoclonal antibody
Formatmab
Target NameMUC20
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MUC20 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MUC20/ MUC-20 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2207
    Target NameMUC20
    Gene ID200958,224116,303886,713400,488023,101080820,504643,100070072
    Gene Symbol and SynonymsMUC-20,MUC20
    Uniprot AccessionQ8N307
    Uniprot Entry NameMUC20_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000176945
    Target ClassificationN/A

    The target: MUC20, gene name: MUC20, also named as MUC-20. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.