Anti-NUMB/ C14orf41/ S171 monoclonal antibody

Anti-NUMB/ C14orf41/ S171 antibody for FACS & in-vivo assay

Target products collectionGo to NUMB/NUMB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2219-Ab-1/ GM-Tg-hg-MP2219-Ab-2Anti-Human NUMB monoclonal antibodyHuman
GM-Tg-rg-MP2219-Ab-1/ GM-Tg-rg-MP2219-Ab-2Anti-Rat NUMB monoclonal antibodyRat
GM-Tg-mg-MP2219-Ab-1/ GM-Tg-mg-MP2219-Ab-2Anti-Mouse NUMB monoclonal antibodyMouse
GM-Tg-cynog-MP2219-Ab-1/ GM-Tg-cynog-MP2219-Ab-2Anti-Cynomolgus/ Rhesus macaque NUMB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2219-Ab-1/ GM-Tg-felg-MP2219-Ab-2Anti-Feline NUMB monoclonal antibodyFeline
GM-Tg-cang-MP2219-Ab-1/ GM-Tg-cang-MP2219-Ab-2Anti-Canine NUMB monoclonal antibodyCanine
GM-Tg-bovg-MP2219-Ab-1/ GM-Tg-bovg-MP2219-Ab-2Anti-Bovine NUMB monoclonal antibodyBovine
GM-Tg-equg-MP2219-Ab-1/ GM-Tg-equg-MP2219-Ab-2Anti-Equine NUMB monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2219-Ab-1/ GM-Tg-hg-MP2219-Ab-2; GM-Tg-rg-MP2219-Ab-1/ GM-Tg-rg-MP2219-Ab-2;
GM-Tg-mg-MP2219-Ab-1/ GM-Tg-mg-MP2219-Ab-2; GM-Tg-cynog-MP2219-Ab-1/ GM-Tg-cynog-MP2219-Ab-2;
GM-Tg-felg-MP2219-Ab-1/ GM-Tg-felg-MP2219-Ab-2; GM-Tg-cang-MP2219-Ab-1/ GM-Tg-cang-MP2219-Ab-2;
GM-Tg-bovg-MP2219-Ab-1/ GM-Tg-bovg-MP2219-Ab-2; GM-Tg-equg-MP2219-Ab-1/ GM-Tg-equg-MP2219-Ab-2
Products NameAnti-NUMB monoclonal antibody
Formatmab
Target NameNUMB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NUMB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NUMB/ C14orf41/ S171 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2219
    Target NameNUMB
    Gene ID8650,18222,29419,696528,480381,101087490,512187,100050235
    Gene Symbol and SynonymsC14orf41,c14_5527,Nb,NUMB,S171
    Uniprot AccessionP49757,Q2LC84
    Uniprot Entry NameNUMB_HUMAN,NUMB_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000133961
    Target ClassificationN/A

    The target: NUMB, gene name: NUMB, also named as C14orf41, S171, c14_5527. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.