Anti-NUP35/ MP-44/ MP44 monoclonal antibody

Anti-NUP35/ MP-44/ MP44 antibody for FACS & in-vivo assay

Target products collectionGo to NUP35/NUP35 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2220-Ab-1/ GM-Tg-hg-MP2220-Ab-2Anti-Human NUP35 monoclonal antibodyHuman
GM-Tg-rg-MP2220-Ab-1/ GM-Tg-rg-MP2220-Ab-2Anti-Rat NUP35 monoclonal antibodyRat
GM-Tg-mg-MP2220-Ab-1/ GM-Tg-mg-MP2220-Ab-2Anti-Mouse NUP35 monoclonal antibodyMouse
GM-Tg-cynog-MP2220-Ab-1/ GM-Tg-cynog-MP2220-Ab-2Anti-Cynomolgus/ Rhesus macaque NUP35 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2220-Ab-1/ GM-Tg-felg-MP2220-Ab-2Anti-Feline NUP35 monoclonal antibodyFeline
GM-Tg-cang-MP2220-Ab-1/ GM-Tg-cang-MP2220-Ab-2Anti-Canine NUP35 monoclonal antibodyCanine
GM-Tg-bovg-MP2220-Ab-1/ GM-Tg-bovg-MP2220-Ab-2Anti-Bovine NUP35 monoclonal antibodyBovine
GM-Tg-equg-MP2220-Ab-1/ GM-Tg-equg-MP2220-Ab-2Anti-Equine NUP35 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2220-Ab-1/ GM-Tg-hg-MP2220-Ab-2; GM-Tg-rg-MP2220-Ab-1/ GM-Tg-rg-MP2220-Ab-2;
GM-Tg-mg-MP2220-Ab-1/ GM-Tg-mg-MP2220-Ab-2; GM-Tg-cynog-MP2220-Ab-1/ GM-Tg-cynog-MP2220-Ab-2;
GM-Tg-felg-MP2220-Ab-1/ GM-Tg-felg-MP2220-Ab-2; GM-Tg-cang-MP2220-Ab-1/ GM-Tg-cang-MP2220-Ab-2;
GM-Tg-bovg-MP2220-Ab-1/ GM-Tg-bovg-MP2220-Ab-2; GM-Tg-equg-MP2220-Ab-1/ GM-Tg-equg-MP2220-Ab-2
Products NameAnti-NUP35 monoclonal antibody
Formatmab
Target NameNUP35
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NUP35 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NUP35/ MP-44/ MP44 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2220
    Target NameNUP35
    Gene ID129401,69482,295692,706497,478830,101085060,511248,100054143
    Gene Symbol and Synonyms2310006I24Rik,35kDa,5330402E05Rik,MP-44,MP44,NO44,NP44,NUP35,NUP53
    Uniprot AccessionQ8NFH5,Q68FY1
    Uniprot Entry NameNUP35_HUMAN,NUP35_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000163002
    Target ClassificationN/A

    The target: NUP35, gene name: NUP35, also named as MP-44, MP44, NP44, NUP53. This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.