Anti-OAS3/ p100/ p100OAS monoclonal antibody

Anti-OAS3/ p100/ p100OAS antibody for FACS & in-vivo assay

Target products collectionGo to OAS3/OAS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2221-Ab-1/ GM-Tg-hg-MP2221-Ab-2Anti-Human OAS3 monoclonal antibodyHuman
GM-Tg-rg-MP2221-Ab-1/ GM-Tg-rg-MP2221-Ab-2Anti-Rat OAS3 monoclonal antibodyRat
GM-Tg-mg-MP2221-Ab-1/ GM-Tg-mg-MP2221-Ab-2Anti-Mouse OAS3 monoclonal antibodyMouse
GM-Tg-cynog-MP2221-Ab-1/ GM-Tg-cynog-MP2221-Ab-2Anti-Cynomolgus/ Rhesus macaque OAS3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2221-Ab-1/ GM-Tg-felg-MP2221-Ab-2Anti-Feline OAS3 monoclonal antibodyFeline
GM-Tg-cang-MP2221-Ab-1/ GM-Tg-cang-MP2221-Ab-2Anti-Canine OAS3 monoclonal antibodyCanine
GM-Tg-bovg-MP2221-Ab-1/ GM-Tg-bovg-MP2221-Ab-2Anti-Bovine OAS3 monoclonal antibodyBovine
GM-Tg-equg-MP2221-Ab-1/ GM-Tg-equg-MP2221-Ab-2Anti-Equine OAS3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2221-Ab-1/ GM-Tg-hg-MP2221-Ab-2; GM-Tg-rg-MP2221-Ab-1/ GM-Tg-rg-MP2221-Ab-2;
GM-Tg-mg-MP2221-Ab-1/ GM-Tg-mg-MP2221-Ab-2; GM-Tg-cynog-MP2221-Ab-1/ GM-Tg-cynog-MP2221-Ab-2;
GM-Tg-felg-MP2221-Ab-1/ GM-Tg-felg-MP2221-Ab-2; GM-Tg-cang-MP2221-Ab-1/ GM-Tg-cang-MP2221-Ab-2;
GM-Tg-bovg-MP2221-Ab-1/ GM-Tg-bovg-MP2221-Ab-2; GM-Tg-equg-MP2221-Ab-1/ GM-Tg-equg-MP2221-Ab-2
Products NameAnti-OAS3 monoclonal antibody
Formatmab
Target NameOAS3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-OAS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species OAS3/ p100/ p100OAS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2221
    Target NameOAS3
    Gene ID4940,246727,494202,712342,477490,101088116,791225
    Gene Symbol and SynonymsOAS3,Oasl10,p100,p100OAS
    Uniprot AccessionQ9Y6K5,Q5MYT7
    Uniprot Entry NameOAS3_HUMAN,OAS3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000111331
    Target ClassificationTumor-associated antigen (TAA)

    The target: OAS3, gene name: OAS3, also named as p100, p100OAS. This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family.  This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L.  This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.