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Anti-OGT1/ OGT/ HINCUT-1 monoclonal antibody
Anti-OGT1/ OGT/ HINCUT-1 antibody for FACS & in-vivo assay
Go to OGT/OGT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2223-Ab-1/ GM-Tg-hg-MP2223-Ab-2 | Anti-Human OGT monoclonal antibody | Human |
| GM-Tg-rg-MP2223-Ab-1/ GM-Tg-rg-MP2223-Ab-2 | Anti-Rat OGT monoclonal antibody | Rat |
| GM-Tg-mg-MP2223-Ab-1/ GM-Tg-mg-MP2223-Ab-2 | Anti-Mouse OGT monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2223-Ab-1/ GM-Tg-cynog-MP2223-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OGT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2223-Ab-1/ GM-Tg-felg-MP2223-Ab-2 | Anti-Feline OGT monoclonal antibody | Feline |
| GM-Tg-cang-MP2223-Ab-1/ GM-Tg-cang-MP2223-Ab-2 | Anti-Canine OGT monoclonal antibody | Canine |
| GM-Tg-bovg-MP2223-Ab-1/ GM-Tg-bovg-MP2223-Ab-2 | Anti-Bovine OGT monoclonal antibody | Bovine |
| GM-Tg-equg-MP2223-Ab-1/ GM-Tg-equg-MP2223-Ab-2 | Anti-Equine OGT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2223-Ab-1/ GM-Tg-hg-MP2223-Ab-2; GM-Tg-rg-MP2223-Ab-1/ GM-Tg-rg-MP2223-Ab-2; GM-Tg-mg-MP2223-Ab-1/ GM-Tg-mg-MP2223-Ab-2; GM-Tg-cynog-MP2223-Ab-1/ GM-Tg-cynog-MP2223-Ab-2; GM-Tg-felg-MP2223-Ab-1/ GM-Tg-felg-MP2223-Ab-2; GM-Tg-cang-MP2223-Ab-1/ GM-Tg-cang-MP2223-Ab-2; GM-Tg-bovg-MP2223-Ab-1/ GM-Tg-bovg-MP2223-Ab-2; GM-Tg-equg-MP2223-Ab-1/ GM-Tg-equg-MP2223-Ab-2 |
| Products Name | Anti-OGT monoclonal antibody |
| Format | mab |
| Target Name | OGT |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OGT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species OGT1/ OGT/ HINCUT-1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000506 | human OGT Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000104 | human OGT AAV plasmid |
| ORF Viral Vector | vGMAD000506 | human OGT Adenovirus particle |
| ORF Viral Vector | vGMAAV000104 | human OGT AAV particle |
| ORF Viral Vector | pGMAAV000024 | mouse Ogt AAV plasmid |
| ORF Viral Vector | vGMAAV000024 | mouse Ogt AAV particle |
Target information
| Target ID | GM-MP2223 |
| Target Name | OGT |
| Gene ID | 8473,108155,26295,698268,480955,101094162,532053,100056148 |
| Gene Symbol and Synonyms | 1110038P24Rik,4831420N21Rik,HINCUT-1,HRNT1,MRX106,O-GLCNAC,OGT,OGT1,Ogtl,XLID106 |
| Uniprot Accession | O15294,P56558 |
| Uniprot Entry Name | OGT1_HUMAN,OGT1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000147162 |
| Target Classification | N/A |
The target: OGT, gene name: OGT, also named as HINCUT-1, HRNT1, MRX106, O-GLCNAC1, OGT. This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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