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Anti-PKP2/ ARVD9 monoclonal antibody
Anti-PKP2/ ARVD9 antibody for FACS & in-vivo assay
Go to PKP2/PKP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2245-Ab-1/ GM-Tg-hg-MP2245-Ab-2 | Anti-Human PKP2 monoclonal antibody | Human |
| GM-Tg-rg-MP2245-Ab-1/ GM-Tg-rg-MP2245-Ab-2 | Anti-Rat PKP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2245-Ab-1/ GM-Tg-mg-MP2245-Ab-2 | Anti-Mouse PKP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2245-Ab-1/ GM-Tg-cynog-MP2245-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PKP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2245-Ab-1/ GM-Tg-felg-MP2245-Ab-2 | Anti-Feline PKP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2245-Ab-1/ GM-Tg-cang-MP2245-Ab-2 | Anti-Canine PKP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2245-Ab-1/ GM-Tg-bovg-MP2245-Ab-2 | Anti-Bovine PKP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2245-Ab-1/ GM-Tg-equg-MP2245-Ab-2 | Anti-Equine PKP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2245-Ab-1/ GM-Tg-hg-MP2245-Ab-2; GM-Tg-rg-MP2245-Ab-1/ GM-Tg-rg-MP2245-Ab-2; GM-Tg-mg-MP2245-Ab-1/ GM-Tg-mg-MP2245-Ab-2; GM-Tg-cynog-MP2245-Ab-1/ GM-Tg-cynog-MP2245-Ab-2; GM-Tg-felg-MP2245-Ab-1/ GM-Tg-felg-MP2245-Ab-2; GM-Tg-cang-MP2245-Ab-1/ GM-Tg-cang-MP2245-Ab-2; GM-Tg-bovg-MP2245-Ab-1/ GM-Tg-bovg-MP2245-Ab-2; GM-Tg-equg-MP2245-Ab-1/ GM-Tg-equg-MP2245-Ab-2 |
| Products Name | Anti-PKP2 monoclonal antibody |
| Format | mab |
| Target Name | PKP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PKP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PKP2/ ARVD9 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000468 | human PKP2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000468 | human PKP2 Lentivirus particle |
Target information
| Target ID | GM-MP2245 |
| Target Name | PKP2 |
| Gene ID | 5318,67451,287925,100429378,486613,101091710,537784,100070065 |
| Gene Symbol and Synonyms | 1200008D14Rik,1200012P04Rik,ARVD9,PKP2,Pkp2l |
| Uniprot Accession | Q99959,F1M7L9 |
| Uniprot Entry Name | PKP2_HUMAN,F1M7L9_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000057294 |
| Target Classification | N/A |
The target: PKP2, gene name: PKP2, also named as ARVD9. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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