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Anti-PKP4/ p0071 monoclonal antibody
Anti-PKP4/ p0071 antibody for FACS & in-vivo assay
Go to PKP4/PKP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2247-Ab-1/ GM-Tg-hg-MP2247-Ab-2 | Anti-Human PKP4 monoclonal antibody | Human |
| GM-Tg-rg-MP2247-Ab-1/ GM-Tg-rg-MP2247-Ab-2 | Anti-Rat PKP4 monoclonal antibody | Rat |
| GM-Tg-mg-MP2247-Ab-1/ GM-Tg-mg-MP2247-Ab-2 | Anti-Mouse PKP4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2247-Ab-1/ GM-Tg-cynog-MP2247-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PKP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2247-Ab-1/ GM-Tg-felg-MP2247-Ab-2 | Anti-Feline PKP4 monoclonal antibody | Feline |
| GM-Tg-cang-MP2247-Ab-1/ GM-Tg-cang-MP2247-Ab-2 | Anti-Canine PKP4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2247-Ab-1/ GM-Tg-bovg-MP2247-Ab-2 | Anti-Bovine PKP4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2247-Ab-1/ GM-Tg-equg-MP2247-Ab-2 | Anti-Equine PKP4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2247-Ab-1/ GM-Tg-hg-MP2247-Ab-2; GM-Tg-rg-MP2247-Ab-1/ GM-Tg-rg-MP2247-Ab-2; GM-Tg-mg-MP2247-Ab-1/ GM-Tg-mg-MP2247-Ab-2; GM-Tg-cynog-MP2247-Ab-1/ GM-Tg-cynog-MP2247-Ab-2; GM-Tg-felg-MP2247-Ab-1/ GM-Tg-felg-MP2247-Ab-2; GM-Tg-cang-MP2247-Ab-1/ GM-Tg-cang-MP2247-Ab-2; GM-Tg-bovg-MP2247-Ab-1/ GM-Tg-bovg-MP2247-Ab-2; GM-Tg-equg-MP2247-Ab-1/ GM-Tg-equg-MP2247-Ab-2 |
| Products Name | Anti-PKP4 monoclonal antibody |
| Format | mab |
| Target Name | PKP4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PKP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PKP4/ p0071 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2247 |
| Target Name | PKP4 |
| Gene ID | 8502,227937,295625,698576,478759,101092041,281406,100050975 |
| Gene Symbol and Synonyms | 5031422I09Rik,9430019K17Rik,Armrp,p0071,PKP4 |
| Uniprot Accession | Q99569 |
| Uniprot Entry Name | PKP4_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000144283 |
| Target Classification | N/A |
The target: PKP4, gene name: PKP4, also named as p0071. Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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