Anti-PLCD3/ PLC-delta-3 monoclonal antibody

Anti-PLCD3/ PLC-delta-3 antibody for FACS & in-vivo assay

Target products collectionGo to PLCD3/PLCD3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2248-Ab-1/ GM-Tg-hg-MP2248-Ab-2Anti-Human PLCD3 monoclonal antibodyHuman
GM-Tg-rg-MP2248-Ab-1/ GM-Tg-rg-MP2248-Ab-2Anti-Rat PLCD3 monoclonal antibodyRat
GM-Tg-mg-MP2248-Ab-1/ GM-Tg-mg-MP2248-Ab-2Anti-Mouse PLCD3 monoclonal antibodyMouse
GM-Tg-cynog-MP2248-Ab-1/ GM-Tg-cynog-MP2248-Ab-2Anti-Cynomolgus/ Rhesus macaque PLCD3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2248-Ab-1/ GM-Tg-felg-MP2248-Ab-2Anti-Feline PLCD3 monoclonal antibodyFeline
GM-Tg-cang-MP2248-Ab-1/ GM-Tg-cang-MP2248-Ab-2Anti-Canine PLCD3 monoclonal antibodyCanine
GM-Tg-bovg-MP2248-Ab-1/ GM-Tg-bovg-MP2248-Ab-2Anti-Bovine PLCD3 monoclonal antibodyBovine
GM-Tg-equg-MP2248-Ab-1/ GM-Tg-equg-MP2248-Ab-2Anti-Equine PLCD3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2248-Ab-1/ GM-Tg-hg-MP2248-Ab-2; GM-Tg-rg-MP2248-Ab-1/ GM-Tg-rg-MP2248-Ab-2;
GM-Tg-mg-MP2248-Ab-1/ GM-Tg-mg-MP2248-Ab-2; GM-Tg-cynog-MP2248-Ab-1/ GM-Tg-cynog-MP2248-Ab-2;
GM-Tg-felg-MP2248-Ab-1/ GM-Tg-felg-MP2248-Ab-2; GM-Tg-cang-MP2248-Ab-1/ GM-Tg-cang-MP2248-Ab-2;
GM-Tg-bovg-MP2248-Ab-1/ GM-Tg-bovg-MP2248-Ab-2; GM-Tg-equg-MP2248-Ab-1/ GM-Tg-equg-MP2248-Ab-2
Products NameAnti-PLCD3 monoclonal antibody
Formatmab
Target NamePLCD3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PLCD3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PLCD3/ PLC-delta-3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2248
    Target NamePLCD3
    Gene ID113026,72469,287745,715924,490929,101086518,513057,100064142
    Gene Symbol and Synonyms2610205J15Rik,mKIAA1964,PLC-delta-3,PLCD3
    Uniprot AccessionQ8N3E9
    Uniprot Entry NamePLCD3_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000161714
    Target ClassificationN/A

    The target: PLCD3, gene name: PLCD3, also named as PLC-delta-3. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.