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Anti-LIPB1/ PPFIBP1/ L2 monoclonal antibody
Anti-LIPB1/ PPFIBP1/ L2 antibody for FACS & in-vivo assay
Go to PPFIBP1/PPFIBP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2259-Ab-1/ GM-Tg-hg-MP2259-Ab-2 | Anti-Human PPFIBP1 monoclonal antibody | Human |
| GM-Tg-rg-MP2259-Ab-1/ GM-Tg-rg-MP2259-Ab-2 | Anti-Rat PPFIBP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2259-Ab-1/ GM-Tg-mg-MP2259-Ab-2 | Anti-Mouse PPFIBP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2259-Ab-1/ GM-Tg-cynog-MP2259-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPFIBP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2259-Ab-1/ GM-Tg-felg-MP2259-Ab-2 | Anti-Feline PPFIBP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2259-Ab-1/ GM-Tg-cang-MP2259-Ab-2 | Anti-Canine PPFIBP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2259-Ab-1/ GM-Tg-bovg-MP2259-Ab-2 | Anti-Bovine PPFIBP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2259-Ab-1/ GM-Tg-equg-MP2259-Ab-2 | Anti-Equine PPFIBP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2259-Ab-1/ GM-Tg-hg-MP2259-Ab-2; GM-Tg-rg-MP2259-Ab-1/ GM-Tg-rg-MP2259-Ab-2; GM-Tg-mg-MP2259-Ab-1/ GM-Tg-mg-MP2259-Ab-2; GM-Tg-cynog-MP2259-Ab-1/ GM-Tg-cynog-MP2259-Ab-2; GM-Tg-felg-MP2259-Ab-1/ GM-Tg-felg-MP2259-Ab-2; GM-Tg-cang-MP2259-Ab-1/ GM-Tg-cang-MP2259-Ab-2; GM-Tg-bovg-MP2259-Ab-1/ GM-Tg-bovg-MP2259-Ab-2; GM-Tg-equg-MP2259-Ab-1/ GM-Tg-equg-MP2259-Ab-2 |
| Products Name | Anti-PPFIBP1 monoclonal antibody |
| Format | mab |
| Target Name | PPFIBP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPFIBP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LIPB1/ PPFIBP1/ L2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2259 |
| Target Name | PPFIBP1 |
| Gene ID | 8496,67533,312855,709742,486623,101082578,407130,100064684 |
| Gene Symbol and Synonyms | 4632409B19Rik,hSGT2,hSgt2p,L2,lip beta1,NEDSMBA,PPFIBP1,SGT2 |
| Uniprot Accession | Q86W92 |
| Uniprot Entry Name | LIPB1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000110841 |
| Target Classification | N/A |
The target: PPFIBP1, gene name: PPFIBP1, also named as L2, SGT2, hSGT2, hSgt2p. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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