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Anti-PP16A/ PPP1R16A/ MYPT3 monoclonal antibody
Anti-PP16A/ PPP1R16A/ MYPT3 antibody for FACS & in-vivo assay
Go to PPP1R16A/PPP1R16A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2263-Ab-1/ GM-Tg-hg-MP2263-Ab-2 | Anti-Human PPP1R16A monoclonal antibody | Human |
| GM-Tg-rg-MP2263-Ab-1/ GM-Tg-rg-MP2263-Ab-2 | Anti-Rat PPP1R16A monoclonal antibody | Rat |
| GM-Tg-mg-MP2263-Ab-1/ GM-Tg-mg-MP2263-Ab-2 | Anti-Mouse PPP1R16A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2263-Ab-1/ GM-Tg-cynog-MP2263-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPP1R16A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2263-Ab-1/ GM-Tg-felg-MP2263-Ab-2 | Anti-Feline PPP1R16A monoclonal antibody | Feline |
| GM-Tg-cang-MP2263-Ab-1/ GM-Tg-cang-MP2263-Ab-2 | Anti-Canine PPP1R16A monoclonal antibody | Canine |
| GM-Tg-bovg-MP2263-Ab-1/ GM-Tg-bovg-MP2263-Ab-2 | Anti-Bovine PPP1R16A monoclonal antibody | Bovine |
| GM-Tg-equg-MP2263-Ab-1/ GM-Tg-equg-MP2263-Ab-2 | Anti-Equine PPP1R16A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2263-Ab-1/ GM-Tg-hg-MP2263-Ab-2; GM-Tg-rg-MP2263-Ab-1/ GM-Tg-rg-MP2263-Ab-2; GM-Tg-mg-MP2263-Ab-1/ GM-Tg-mg-MP2263-Ab-2; GM-Tg-cynog-MP2263-Ab-1/ GM-Tg-cynog-MP2263-Ab-2; GM-Tg-felg-MP2263-Ab-1/ GM-Tg-felg-MP2263-Ab-2; GM-Tg-cang-MP2263-Ab-1/ GM-Tg-cang-MP2263-Ab-2; GM-Tg-bovg-MP2263-Ab-1/ GM-Tg-bovg-MP2263-Ab-2; GM-Tg-equg-MP2263-Ab-1/ GM-Tg-equg-MP2263-Ab-2 |
| Products Name | Anti-PPP1R16A monoclonal antibody |
| Format | mab |
| Target Name | PPP1R16A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPP1R16A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PP16A/ PPP1R16A/ MYPT3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2263 |
| Target Name | PPP1R16A |
| Gene ID | 84988,73062,362944,702995,482099,101081956,508701,100147459 |
| Gene Symbol and Synonyms | 2900084E10Rik,MYPT3,PPP1R16A |
| Uniprot Accession | Q96I34 |
| Uniprot Entry Name | PP16A_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000160972 |
| Target Classification | N/A |
The target: PPP1R16A, gene name: PPP1R16A, also named as MYPT3. Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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