Anti-PP6R3/ PPP6R3/ C11orf23 monoclonal antibody

Anti-PP6R3/ PPP6R3/ C11orf23 antibody for FACS & in-vivo assay

Target products collectionGo to PPP6R3/PPP6R3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2266-Ab-1/ GM-Tg-hg-MP2266-Ab-2Anti-Human PPP6R3 monoclonal antibodyHuman
GM-Tg-rg-MP2266-Ab-1/ GM-Tg-rg-MP2266-Ab-2Anti-Rat PPP6R3 monoclonal antibodyRat
GM-Tg-mg-MP2266-Ab-1/ GM-Tg-mg-MP2266-Ab-2Anti-Mouse PPP6R3 monoclonal antibodyMouse
GM-Tg-cynog-MP2266-Ab-1/ GM-Tg-cynog-MP2266-Ab-2Anti-Cynomolgus/ Rhesus macaque PPP6R3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2266-Ab-1/ GM-Tg-felg-MP2266-Ab-2Anti-Feline PPP6R3 monoclonal antibodyFeline
GM-Tg-cang-MP2266-Ab-1/ GM-Tg-cang-MP2266-Ab-2Anti-Canine PPP6R3 monoclonal antibodyCanine
GM-Tg-bovg-MP2266-Ab-1/ GM-Tg-bovg-MP2266-Ab-2Anti-Bovine PPP6R3 monoclonal antibodyBovine
GM-Tg-equg-MP2266-Ab-1/ GM-Tg-equg-MP2266-Ab-2Anti-Equine PPP6R3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2266-Ab-1/ GM-Tg-hg-MP2266-Ab-2; GM-Tg-rg-MP2266-Ab-1/ GM-Tg-rg-MP2266-Ab-2;
GM-Tg-mg-MP2266-Ab-1/ GM-Tg-mg-MP2266-Ab-2; GM-Tg-cynog-MP2266-Ab-1/ GM-Tg-cynog-MP2266-Ab-2;
GM-Tg-felg-MP2266-Ab-1/ GM-Tg-felg-MP2266-Ab-2; GM-Tg-cang-MP2266-Ab-1/ GM-Tg-cang-MP2266-Ab-2;
GM-Tg-bovg-MP2266-Ab-1/ GM-Tg-bovg-MP2266-Ab-2; GM-Tg-equg-MP2266-Ab-1/ GM-Tg-equg-MP2266-Ab-2
Products NameAnti-PPP6R3 monoclonal antibody
Formatmab
Target NamePPP6R3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PPP6R3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PP6R3/ PPP6R3/ C11orf23 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2266
    Target NamePPP6R3
    Gene ID55291,52036,309144,710120,483688,101094955,515218,100053490
    Gene Symbol and Synonyms4930528G08Rik,9130026N02Rik,C11orf23,D19Bwg1430e,D19Ertd703e,mKIAA1558,PP6R3,Ppcs3,PPP6R3,Ppp6r3-ps1,Pptcs3,RGD1307145,SAP190,SAPL,SAPLa,SAPS3,Saps3-ps1
    Uniprot AccessionQ5H9R7
    Uniprot Entry NamePP6R3_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000110075
    Target ClassificationN/A

    The target: PPP6R3, gene name: PPP6R3, also named as C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3. Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.