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Anti-PRC1/ ASE1 monoclonal antibody
Anti-PRC1/ ASE1 antibody for FACS & in-vivo assay
Go to PRC1/PRC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2267-Ab-1/ GM-Tg-hg-MP2267-Ab-2 | Anti-Human PRC1 monoclonal antibody | Human |
| GM-Tg-rg-MP2267-Ab-1/ GM-Tg-rg-MP2267-Ab-2 | Anti-Rat PRC1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2267-Ab-1/ GM-Tg-mg-MP2267-Ab-2 | Anti-Mouse PRC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2267-Ab-1/ GM-Tg-cynog-MP2267-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2267-Ab-1/ GM-Tg-felg-MP2267-Ab-2 | Anti-Feline PRC1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2267-Ab-1/ GM-Tg-cang-MP2267-Ab-2 | Anti-Canine PRC1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2267-Ab-1/ GM-Tg-bovg-MP2267-Ab-2 | Anti-Bovine PRC1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2267-Ab-1/ GM-Tg-equg-MP2267-Ab-2 | Anti-Equine PRC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2267-Ab-1/ GM-Tg-hg-MP2267-Ab-2; GM-Tg-rg-MP2267-Ab-1/ GM-Tg-rg-MP2267-Ab-2; GM-Tg-mg-MP2267-Ab-1/ GM-Tg-mg-MP2267-Ab-2; GM-Tg-cynog-MP2267-Ab-1/ GM-Tg-cynog-MP2267-Ab-2; GM-Tg-felg-MP2267-Ab-1/ GM-Tg-felg-MP2267-Ab-2; GM-Tg-cang-MP2267-Ab-1/ GM-Tg-cang-MP2267-Ab-2; GM-Tg-bovg-MP2267-Ab-1/ GM-Tg-bovg-MP2267-Ab-2; GM-Tg-equg-MP2267-Ab-1/ GM-Tg-equg-MP2267-Ab-2 |
| Products Name | Anti-PRC1 monoclonal antibody |
| Format | mab |
| Target Name | PRC1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PRC1/ ASE1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003908 | human PRC1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003908 | human PRC1 Lentivirus particle |
| ORF Viral Vector | pGMLPm005071 | mouse Prc1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005071 | mouse Prc1 Lentivirus particle |
Target information
| Target ID | GM-MP2267 |
| Target Name | PRC1 |
| Gene ID | 9055,233406,308761,710182,488742,101088580,767818,100069001 |
| Gene Symbol and Synonyms | ASE1,D7Ertd348e,PRC1 |
| Uniprot Accession | O43663 |
| Uniprot Entry Name | PRC1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000198901 |
| Target Classification | N/A |
The target: PRC1, gene name: PRC1, also named as ASE1. This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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