Anti-PRAX/ PRX/ CMT4F monoclonal antibody

Anti-PRAX/ PRX/ CMT4F antibody for FACS & in-vivo assay

Target products collectionGo to PRX/PRX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2270-Ab-1/ GM-Tg-hg-MP2270-Ab-2Anti-Human PRX monoclonal antibodyHuman
GM-Tg-rg-MP2270-Ab-1/ GM-Tg-rg-MP2270-Ab-2Anti-Rat PRX monoclonal antibodyRat
GM-Tg-mg-MP2270-Ab-1/ GM-Tg-mg-MP2270-Ab-2Anti-Mouse PRX monoclonal antibodyMouse
GM-Tg-cynog-MP2270-Ab-1/ GM-Tg-cynog-MP2270-Ab-2Anti-Cynomolgus/ Rhesus macaque PRX monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2270-Ab-1/ GM-Tg-felg-MP2270-Ab-2Anti-Feline PRX monoclonal antibodyFeline
GM-Tg-cang-MP2270-Ab-1/ GM-Tg-cang-MP2270-Ab-2Anti-Canine PRX monoclonal antibodyCanine
GM-Tg-bovg-MP2270-Ab-1/ GM-Tg-bovg-MP2270-Ab-2Anti-Bovine PRX monoclonal antibodyBovine
GM-Tg-equg-MP2270-Ab-1/ GM-Tg-equg-MP2270-Ab-2Anti-Equine PRX monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2270-Ab-1/ GM-Tg-hg-MP2270-Ab-2; GM-Tg-rg-MP2270-Ab-1/ GM-Tg-rg-MP2270-Ab-2;
GM-Tg-mg-MP2270-Ab-1/ GM-Tg-mg-MP2270-Ab-2; GM-Tg-cynog-MP2270-Ab-1/ GM-Tg-cynog-MP2270-Ab-2;
GM-Tg-felg-MP2270-Ab-1/ GM-Tg-felg-MP2270-Ab-2; GM-Tg-cang-MP2270-Ab-1/ GM-Tg-cang-MP2270-Ab-2;
GM-Tg-bovg-MP2270-Ab-1/ GM-Tg-bovg-MP2270-Ab-2; GM-Tg-equg-MP2270-Ab-1/ GM-Tg-equg-MP2270-Ab-2
Products NameAnti-PRX monoclonal antibody
Formatmab
Target NamePRX
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PRX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PRAX/ PRX/ CMT4F VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2270
    Target NamePRX
    Gene ID57716,19153,78960,702329,484501,101093226,520296,100068085
    Gene Symbol and SynonymsCMT4F,L-Periaxin,PRX
    Uniprot AccessionQ9BXM0,Q63425,E1BM58
    Uniprot Entry NamePRAX_HUMAN,PRAX_RAT,PRAX_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000105227
    Target ClassificationN/A

    The target: PRX, gene name: PRX, also named as CMT4F. This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.