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Anti-RAB23/ HSPC137 monoclonal antibody
Anti-RAB23/ HSPC137 antibody for FACS & in-vivo assay
Go to RAB23/RAB23 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2274-Ab-1/ GM-Tg-hg-MP2274-Ab-2 | Anti-Human RAB23 monoclonal antibody | Human |
| GM-Tg-rg-MP2274-Ab-1/ GM-Tg-rg-MP2274-Ab-2 | Anti-Rat RAB23 monoclonal antibody | Rat |
| GM-Tg-mg-MP2274-Ab-1/ GM-Tg-mg-MP2274-Ab-2 | Anti-Mouse RAB23 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2274-Ab-1/ GM-Tg-cynog-MP2274-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAB23 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2274-Ab-1/ GM-Tg-felg-MP2274-Ab-2 | Anti-Feline RAB23 monoclonal antibody | Feline |
| GM-Tg-cang-MP2274-Ab-1/ GM-Tg-cang-MP2274-Ab-2 | Anti-Canine RAB23 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2274-Ab-1/ GM-Tg-bovg-MP2274-Ab-2 | Anti-Bovine RAB23 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2274-Ab-1/ GM-Tg-equg-MP2274-Ab-2 | Anti-Equine RAB23 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2274-Ab-1/ GM-Tg-hg-MP2274-Ab-2; GM-Tg-rg-MP2274-Ab-1/ GM-Tg-rg-MP2274-Ab-2; GM-Tg-mg-MP2274-Ab-1/ GM-Tg-mg-MP2274-Ab-2; GM-Tg-cynog-MP2274-Ab-1/ GM-Tg-cynog-MP2274-Ab-2; GM-Tg-felg-MP2274-Ab-1/ GM-Tg-felg-MP2274-Ab-2; GM-Tg-cang-MP2274-Ab-1/ GM-Tg-cang-MP2274-Ab-2; GM-Tg-bovg-MP2274-Ab-1/ GM-Tg-bovg-MP2274-Ab-2; GM-Tg-equg-MP2274-Ab-1/ GM-Tg-equg-MP2274-Ab-2 |
| Products Name | Anti-RAB23 monoclonal antibody |
| Format | mab |
| Target Name | RAB23 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RAB23 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RAB23/ HSPC137 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000222 | human RAB23 Lentivirus particle |
| ORF Viral Vector | pGMLP000222 | human RAB23 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001116 | mouse Rab23 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001116 | mouse Rab23 Lentivirus particle |
Target information
| Target ID | GM-MP2274 |
| Target Name | RAB23 |
| Gene ID | 51715,19335,367242,712860,481854,101100469,618588,100070075 |
| Gene Symbol and Synonyms | HSPC137,opb,opb2,rab-15,RAB23,Rab23-like |
| Uniprot Accession | Q9ULC3 |
| Uniprot Entry Name | RAB23_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112210 |
| Target Classification | N/A |
The target: RAB23, gene name: RAB23, also named as HSPC137. This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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