Anti-RAS4B/ RASA4B monoclonal antibody

Anti-RAS4B/ RASA4B antibody for FACS & in-vivo assay

Target products collectionGo to RASA4B/RASA4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2282-Ab-1/ GM-Tg-hg-MP2282-Ab-2Anti-Human RASA4B monoclonal antibodyHuman
GM-Tg-rg-MP2282-Ab-1/ GM-Tg-rg-MP2282-Ab-2Anti-Rat RASA4B monoclonal antibodyRat
GM-Tg-mg-MP2282-Ab-1/ GM-Tg-mg-MP2282-Ab-2Anti-Mouse RASA4B monoclonal antibodyMouse
GM-Tg-cynog-MP2282-Ab-1/ GM-Tg-cynog-MP2282-Ab-2Anti-Cynomolgus/ Rhesus macaque RASA4B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2282-Ab-1/ GM-Tg-felg-MP2282-Ab-2Anti-Feline RASA4B monoclonal antibodyFeline
GM-Tg-cang-MP2282-Ab-1/ GM-Tg-cang-MP2282-Ab-2Anti-Canine RASA4B monoclonal antibodyCanine
GM-Tg-bovg-MP2282-Ab-1/ GM-Tg-bovg-MP2282-Ab-2Anti-Bovine RASA4B monoclonal antibodyBovine
GM-Tg-equg-MP2282-Ab-1/ GM-Tg-equg-MP2282-Ab-2Anti-Equine RASA4B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2282-Ab-1/ GM-Tg-hg-MP2282-Ab-2; GM-Tg-rg-MP2282-Ab-1/ GM-Tg-rg-MP2282-Ab-2;
GM-Tg-mg-MP2282-Ab-1/ GM-Tg-mg-MP2282-Ab-2; GM-Tg-cynog-MP2282-Ab-1/ GM-Tg-cynog-MP2282-Ab-2;
GM-Tg-felg-MP2282-Ab-1/ GM-Tg-felg-MP2282-Ab-2; GM-Tg-cang-MP2282-Ab-1/ GM-Tg-cang-MP2282-Ab-2;
GM-Tg-bovg-MP2282-Ab-1/ GM-Tg-bovg-MP2282-Ab-2; GM-Tg-equg-MP2282-Ab-1/ GM-Tg-equg-MP2282-Ab-2
Products NameAnti-RASA4B monoclonal antibody
Formatmab
Target NameRASA4B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RASA4B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RAS4B/ RASA4B VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2282
    Target NameRASA4B
    Gene ID100271927,719871,489819,101091420
    Gene Symbol and SynonymsRASA4,RASA4B
    Uniprot AccessionC9J798
    Uniprot Entry NameRAS4B_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000170667
    Target ClassificationN/A

    The target: RASA4B, gene name: RASA4B, also named as . Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.