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Anti-RASL1/ RASAL1/ RASAL monoclonal antibody
Anti-RASL1/ RASAL1/ RASAL antibody for FACS & in-vivo assay
Go to RASAL1/RASAL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2283-Ab-1/ GM-Tg-hg-MP2283-Ab-2 | Anti-Human RASAL1 monoclonal antibody | Human |
| GM-Tg-rg-MP2283-Ab-1/ GM-Tg-rg-MP2283-Ab-2 | Anti-Rat RASAL1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2283-Ab-1/ GM-Tg-mg-MP2283-Ab-2 | Anti-Mouse RASAL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2283-Ab-1/ GM-Tg-cynog-MP2283-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RASAL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2283-Ab-1/ GM-Tg-felg-MP2283-Ab-2 | Anti-Feline RASAL1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2283-Ab-1/ GM-Tg-cang-MP2283-Ab-2 | Anti-Canine RASAL1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2283-Ab-1/ GM-Tg-bovg-MP2283-Ab-2 | Anti-Bovine RASAL1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2283-Ab-1/ GM-Tg-equg-MP2283-Ab-2 | Anti-Equine RASAL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2283-Ab-1/ GM-Tg-hg-MP2283-Ab-2; GM-Tg-rg-MP2283-Ab-1/ GM-Tg-rg-MP2283-Ab-2; GM-Tg-mg-MP2283-Ab-1/ GM-Tg-mg-MP2283-Ab-2; GM-Tg-cynog-MP2283-Ab-1/ GM-Tg-cynog-MP2283-Ab-2; GM-Tg-felg-MP2283-Ab-1/ GM-Tg-felg-MP2283-Ab-2; GM-Tg-cang-MP2283-Ab-1/ GM-Tg-cang-MP2283-Ab-2; GM-Tg-bovg-MP2283-Ab-1/ GM-Tg-bovg-MP2283-Ab-2; GM-Tg-equg-MP2283-Ab-1/ GM-Tg-equg-MP2283-Ab-2 |
| Products Name | Anti-RASAL1 monoclonal antibody |
| Format | mab |
| Target Name | RASAL1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RASAL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RASL1/ RASAL1/ RASAL VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000651 | house mouse Rasal1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000651 | house mouse Rasal1 Adenovirus particle |
Target information
| Target ID | GM-MP2283 |
| Target Name | RASAL1 |
| Gene ID | 8437,19415,360814,714353,486277,101088621,512872,100056699 |
| Gene Symbol and Synonyms | MRASAL,RASAL,RASAL1 |
| Uniprot Accession | O95294 |
| Uniprot Entry Name | RASL1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000111344 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RASAL1, gene name: RASAL1, also named as RASAL. The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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