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Anti-RHES/ RASD2/ Rhes monoclonal antibody
Anti-RHES/ RASD2/ Rhes antibody for FACS & in-vivo assay
Go to RASD2/RASD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2285-Ab-1/ GM-Tg-hg-MP2285-Ab-2 | Anti-Human RASD2 monoclonal antibody | Human |
| GM-Tg-rg-MP2285-Ab-1/ GM-Tg-rg-MP2285-Ab-2 | Anti-Rat RASD2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2285-Ab-1/ GM-Tg-mg-MP2285-Ab-2 | Anti-Mouse RASD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2285-Ab-1/ GM-Tg-cynog-MP2285-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RASD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2285-Ab-1/ GM-Tg-felg-MP2285-Ab-2 | Anti-Feline RASD2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2285-Ab-1/ GM-Tg-cang-MP2285-Ab-2 | Anti-Canine RASD2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2285-Ab-1/ GM-Tg-bovg-MP2285-Ab-2 | Anti-Bovine RASD2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2285-Ab-1/ GM-Tg-equg-MP2285-Ab-2 | Anti-Equine RASD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2285-Ab-1/ GM-Tg-hg-MP2285-Ab-2; GM-Tg-rg-MP2285-Ab-1/ GM-Tg-rg-MP2285-Ab-2; GM-Tg-mg-MP2285-Ab-1/ GM-Tg-mg-MP2285-Ab-2; GM-Tg-cynog-MP2285-Ab-1/ GM-Tg-cynog-MP2285-Ab-2; GM-Tg-felg-MP2285-Ab-1/ GM-Tg-felg-MP2285-Ab-2; GM-Tg-cang-MP2285-Ab-1/ GM-Tg-cang-MP2285-Ab-2; GM-Tg-bovg-MP2285-Ab-1/ GM-Tg-bovg-MP2285-Ab-2; GM-Tg-equg-MP2285-Ab-1/ GM-Tg-equg-MP2285-Ab-2 |
| Products Name | Anti-RASD2 monoclonal antibody |
| Format | mab |
| Target Name | RASD2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RASD2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RHES/ RASD2/ Rhes VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2285 |
| Target Name | RASD2 |
| Gene ID | 23551,75141,171099,719385,481284,101093116,527921,100054386 |
| Gene Symbol and Synonyms | 4930526B11Rik,RASD2,Rhes,TEM-2,TEM2 |
| Uniprot Accession | Q96D21,P63033 |
| Uniprot Entry Name | RHES_HUMAN,RHES_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | IgA glomerulonephritis |
| Gene Ensembl | ENSG00000100302 |
| Target Classification | N/A |
The target: RASD2, gene name: RASD2, also named as Rhes, TEM2. This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
