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Anti-GRP4/ RASGRP4 monoclonal antibody
Anti-GRP4/ RASGRP4 antibody for FACS & in-vivo assay
Go to RASGRP4/RASGRP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2287-Ab-1/ GM-Tg-hg-MP2287-Ab-2 | Anti-Human RASGRP4 monoclonal antibody | Human |
| GM-Tg-rg-MP2287-Ab-1/ GM-Tg-rg-MP2287-Ab-2 | Anti-Rat RASGRP4 monoclonal antibody | Rat |
| GM-Tg-mg-MP2287-Ab-1/ GM-Tg-mg-MP2287-Ab-2 | Anti-Mouse RASGRP4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2287-Ab-1/ GM-Tg-cynog-MP2287-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RASGRP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2287-Ab-1/ GM-Tg-felg-MP2287-Ab-2 | Anti-Feline RASGRP4 monoclonal antibody | Feline |
| GM-Tg-cang-MP2287-Ab-1/ GM-Tg-cang-MP2287-Ab-2 | Anti-Canine RASGRP4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2287-Ab-1/ GM-Tg-bovg-MP2287-Ab-2 | Anti-Bovine RASGRP4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2287-Ab-1/ GM-Tg-equg-MP2287-Ab-2 | Anti-Equine RASGRP4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2287-Ab-1/ GM-Tg-hg-MP2287-Ab-2; GM-Tg-rg-MP2287-Ab-1/ GM-Tg-rg-MP2287-Ab-2; GM-Tg-mg-MP2287-Ab-1/ GM-Tg-mg-MP2287-Ab-2; GM-Tg-cynog-MP2287-Ab-1/ GM-Tg-cynog-MP2287-Ab-2; GM-Tg-felg-MP2287-Ab-1/ GM-Tg-felg-MP2287-Ab-2; GM-Tg-cang-MP2287-Ab-1/ GM-Tg-cang-MP2287-Ab-2; GM-Tg-bovg-MP2287-Ab-1/ GM-Tg-bovg-MP2287-Ab-2; GM-Tg-equg-MP2287-Ab-1/ GM-Tg-equg-MP2287-Ab-2 |
| Products Name | Anti-RASGRP4 monoclonal antibody |
| Format | mab |
| Target Name | RASGRP4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RASGRP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRP4/ RASGRP4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005378 | mouse Rasgrp4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005378 | mouse Rasgrp4 Lentivirus particle |
Target information
| Target ID | GM-MP2287 |
| Target Name | RASGRP4 |
| Gene ID | 115727,233046,170668,719595,484528,101094467,529375,100064247 |
| Gene Symbol and Synonyms | RASGRP4 |
| Uniprot Accession | Q8TDF6,Q8R5I4,Q1LZ97 |
| Uniprot Entry Name | GRP4_HUMAN,GRP4_RAT,GRP4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000171777 |
| Target Classification | N/A |
The target: RASGRP4, gene name: RASGRP4, also named as . The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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