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Anti-RADI/ RDX/ DFNB24 monoclonal antibody
Anti-RADI/ RDX/ DFNB24 antibody for FACS & in-vivo assay
Go to RDX/RDX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2291-Ab-1/ GM-Tg-hg-MP2291-Ab-2 | Anti-Human RDX monoclonal antibody | Human |
| GM-Tg-rg-MP2291-Ab-1/ GM-Tg-rg-MP2291-Ab-2 | Anti-Rat RDX monoclonal antibody | Rat |
| GM-Tg-mg-MP2291-Ab-1/ GM-Tg-mg-MP2291-Ab-2 | Anti-Mouse RDX monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2291-Ab-1/ GM-Tg-cynog-MP2291-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RDX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2291-Ab-1/ GM-Tg-felg-MP2291-Ab-2 | Anti-Feline RDX monoclonal antibody | Feline |
| GM-Tg-cang-MP2291-Ab-1/ GM-Tg-cang-MP2291-Ab-2 | Anti-Canine RDX monoclonal antibody | Canine |
| GM-Tg-bovg-MP2291-Ab-1/ GM-Tg-bovg-MP2291-Ab-2 | Anti-Bovine RDX monoclonal antibody | Bovine |
| GM-Tg-equg-MP2291-Ab-1/ GM-Tg-equg-MP2291-Ab-2 | Anti-Equine RDX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2291-Ab-1/ GM-Tg-hg-MP2291-Ab-2; GM-Tg-rg-MP2291-Ab-1/ GM-Tg-rg-MP2291-Ab-2; GM-Tg-mg-MP2291-Ab-1/ GM-Tg-mg-MP2291-Ab-2; GM-Tg-cynog-MP2291-Ab-1/ GM-Tg-cynog-MP2291-Ab-2; GM-Tg-felg-MP2291-Ab-1/ GM-Tg-felg-MP2291-Ab-2; GM-Tg-cang-MP2291-Ab-1/ GM-Tg-cang-MP2291-Ab-2; GM-Tg-bovg-MP2291-Ab-1/ GM-Tg-bovg-MP2291-Ab-2; GM-Tg-equg-MP2291-Ab-1/ GM-Tg-equg-MP2291-Ab-2 |
| Products Name | Anti-RDX monoclonal antibody |
| Format | mab |
| Target Name | RDX |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RDX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RADI/ RDX/ DFNB24 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003063 | mouse Rdx Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003063 | mouse Rdx Lentivirus particle |
Target information
| Target ID | GM-MP2291 |
| Target Name | RDX |
| Gene ID | 5962,19684,315655,709018,479446,101090715,517111,100061858 |
| Gene Symbol and Synonyms | DFNB24,RDX |
| Uniprot Accession | P35241,Q32LP2 |
| Uniprot Entry Name | RADI_HUMAN,RADI_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000137710 |
| Target Classification | N/A |
The target: RDX, gene name: RDX, also named as DFNB24. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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