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Anti-RELN/ ETL7/ LIS2 monoclonal antibody
Anti-RELN/ ETL7/ LIS2 antibody for FACS & in-vivo assay
Go to RELN/RELN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2292-Ab-1/ GM-Tg-hg-MP2292-Ab-2 | Anti-Human RELN monoclonal antibody | Human |
| GM-Tg-rg-MP2292-Ab-1/ GM-Tg-rg-MP2292-Ab-2 | Anti-Rat RELN monoclonal antibody | Rat |
| GM-Tg-mg-MP2292-Ab-1/ GM-Tg-mg-MP2292-Ab-2 | Anti-Mouse RELN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2292-Ab-1/ GM-Tg-cynog-MP2292-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RELN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2292-Ab-1/ GM-Tg-felg-MP2292-Ab-2 | Anti-Feline RELN monoclonal antibody | Feline |
| GM-Tg-cang-MP2292-Ab-1/ GM-Tg-cang-MP2292-Ab-2 | Anti-Canine RELN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2292-Ab-1/ GM-Tg-bovg-MP2292-Ab-2 | Anti-Bovine RELN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2292-Ab-1/ GM-Tg-equg-MP2292-Ab-2 | Anti-Equine RELN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2292-Ab-1/ GM-Tg-hg-MP2292-Ab-2; GM-Tg-rg-MP2292-Ab-1/ GM-Tg-rg-MP2292-Ab-2; GM-Tg-mg-MP2292-Ab-1/ GM-Tg-mg-MP2292-Ab-2; GM-Tg-cynog-MP2292-Ab-1/ GM-Tg-cynog-MP2292-Ab-2; GM-Tg-felg-MP2292-Ab-1/ GM-Tg-felg-MP2292-Ab-2; GM-Tg-cang-MP2292-Ab-1/ GM-Tg-cang-MP2292-Ab-2; GM-Tg-bovg-MP2292-Ab-1/ GM-Tg-bovg-MP2292-Ab-2; GM-Tg-equg-MP2292-Ab-1/ GM-Tg-equg-MP2292-Ab-2 |
| Products Name | Anti-RELN monoclonal antibody |
| Format | mab |
| Target Name | RELN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RELN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RELN/ ETL7/ LIS2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2292 |
| Target Name | RELN |
| Gene ID | 5649,19699,24718,696372,483273,101085703,281450,100058621 |
| Gene Symbol and Synonyms | ETL7,LIS2,PRO1598,Reelen,reeler,RELN,RL |
| Uniprot Accession | P78509,P58751,Q9N117 |
| Uniprot Entry Name | RELN_HUMAN,RELN_RAT,RELN_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | bipolar disorder, Autism, major depression, schizophrenia |
| Gene Ensembl | ENSG00000189056 |
| Target Classification | N/A |
The target: RELN, gene name: RELN, also named as ETL7, LIS2, PRO1598, RL. This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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