Anti-RGP1/ KIAA0258 monoclonal antibody

Anti-RGP1/ KIAA0258 antibody for FACS & in-vivo assay

Target products collectionGo to RGP1/RGP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2294-Ab-1/ GM-Tg-hg-MP2294-Ab-2Anti-Human RGP1 monoclonal antibodyHuman
GM-Tg-rg-MP2294-Ab-1/ GM-Tg-rg-MP2294-Ab-2Anti-Rat RGP1 monoclonal antibodyRat
GM-Tg-mg-MP2294-Ab-1/ GM-Tg-mg-MP2294-Ab-2Anti-Mouse RGP1 monoclonal antibodyMouse
GM-Tg-cynog-MP2294-Ab-1/ GM-Tg-cynog-MP2294-Ab-2Anti-Cynomolgus/ Rhesus macaque RGP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2294-Ab-1/ GM-Tg-felg-MP2294-Ab-2Anti-Feline RGP1 monoclonal antibodyFeline
GM-Tg-cang-MP2294-Ab-1/ GM-Tg-cang-MP2294-Ab-2Anti-Canine RGP1 monoclonal antibodyCanine
GM-Tg-bovg-MP2294-Ab-1/ GM-Tg-bovg-MP2294-Ab-2Anti-Bovine RGP1 monoclonal antibodyBovine
GM-Tg-equg-MP2294-Ab-1/ GM-Tg-equg-MP2294-Ab-2Anti-Equine RGP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2294-Ab-1/ GM-Tg-hg-MP2294-Ab-2; GM-Tg-rg-MP2294-Ab-1/ GM-Tg-rg-MP2294-Ab-2;
GM-Tg-mg-MP2294-Ab-1/ GM-Tg-mg-MP2294-Ab-2; GM-Tg-cynog-MP2294-Ab-1/ GM-Tg-cynog-MP2294-Ab-2;
GM-Tg-felg-MP2294-Ab-1/ GM-Tg-felg-MP2294-Ab-2; GM-Tg-cang-MP2294-Ab-1/ GM-Tg-cang-MP2294-Ab-2;
GM-Tg-bovg-MP2294-Ab-1/ GM-Tg-bovg-MP2294-Ab-2; GM-Tg-equg-MP2294-Ab-1/ GM-Tg-equg-MP2294-Ab-2
Products NameAnti-RGP1 monoclonal antibody
Formatmab
Target NameRGP1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RGP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RGP1/ KIAA0258 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2294
    Target NameRGP1
    Gene ID9827,242406,313493,695936,100684169,101093809,539393,100067753
    Gene Symbol and Synonyms1110029E03Rik,F730001J03,KIAA0258,mKIAA0258,RGD1311757,RGP1
    Uniprot AccessionQ92546,Q2T9P3
    Uniprot Entry NameRGP1_HUMAN,RGP1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000107185
    Target ClassificationN/A

    The target: RGP1, gene name: RGP1, also named as KIAA0258. Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.