Anti-RGS3/ C2PA/ RGP3 monoclonal antibody

Anti-RGS3/ C2PA/ RGP3 antibody for FACS & in-vivo assay

Target products collectionGo to RGS3/RGS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2298-Ab-1/ GM-Tg-hg-MP2298-Ab-2Anti-Human RGS3 monoclonal antibodyHuman
GM-Tg-rg-MP2298-Ab-1/ GM-Tg-rg-MP2298-Ab-2Anti-Rat RGS3 monoclonal antibodyRat
GM-Tg-mg-MP2298-Ab-1/ GM-Tg-mg-MP2298-Ab-2Anti-Mouse RGS3 monoclonal antibodyMouse
GM-Tg-cynog-MP2298-Ab-1/ GM-Tg-cynog-MP2298-Ab-2Anti-Cynomolgus/ Rhesus macaque RGS3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2298-Ab-1/ GM-Tg-felg-MP2298-Ab-2Anti-Feline RGS3 monoclonal antibodyFeline
GM-Tg-cang-MP2298-Ab-1/ GM-Tg-cang-MP2298-Ab-2Anti-Canine RGS3 monoclonal antibodyCanine
GM-Tg-bovg-MP2298-Ab-1/ GM-Tg-bovg-MP2298-Ab-2Anti-Bovine RGS3 monoclonal antibodyBovine
GM-Tg-equg-MP2298-Ab-1/ GM-Tg-equg-MP2298-Ab-2Anti-Equine RGS3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2298-Ab-1/ GM-Tg-hg-MP2298-Ab-2; GM-Tg-rg-MP2298-Ab-1/ GM-Tg-rg-MP2298-Ab-2;
GM-Tg-mg-MP2298-Ab-1/ GM-Tg-mg-MP2298-Ab-2; GM-Tg-cynog-MP2298-Ab-1/ GM-Tg-cynog-MP2298-Ab-2;
GM-Tg-felg-MP2298-Ab-1/ GM-Tg-felg-MP2298-Ab-2; GM-Tg-cang-MP2298-Ab-1/ GM-Tg-cang-MP2298-Ab-2;
GM-Tg-bovg-MP2298-Ab-1/ GM-Tg-bovg-MP2298-Ab-2; GM-Tg-equg-MP2298-Ab-1/ GM-Tg-equg-MP2298-Ab-2
Products NameAnti-RGS3 monoclonal antibody
Formatmab
Target NameRGS3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RGS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RGS3/ C2PA/ RGP3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2298
    Target NameRGS3
    Gene ID5998,50780,54293,709612,610879,101097523,527349,100052488
    Gene Symbol and Synonyms4930506N09Rik,C2PA,C2PA-RGS3,PDZ-RGS3,RGP3,RGS3,RGS3S,SRB-RGS
    Uniprot AccessionP49796,P49797
    Uniprot Entry NameRGS3_HUMAN,RGS3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000138835
    Target ClassificationN/A

    The target: RGS3, gene name: RGS3, also named as C2PA, RGP3. This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.