Anti-XRP2/ RP2/ DELXp11.3 monoclonal antibody

Anti-XRP2/ RP2/ DELXp11.3 antibody for FACS & in-vivo assay

Target products collectionGo to RP2/RP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2307-Ab-1/ GM-Tg-hg-MP2307-Ab-2Anti-Human RP2 monoclonal antibodyHuman
GM-Tg-rg-MP2307-Ab-1/ GM-Tg-rg-MP2307-Ab-2Anti-Rat RP2 monoclonal antibodyRat
GM-Tg-mg-MP2307-Ab-1/ GM-Tg-mg-MP2307-Ab-2Anti-Mouse RP2 monoclonal antibodyMouse
GM-Tg-cynog-MP2307-Ab-1/ GM-Tg-cynog-MP2307-Ab-2Anti-Cynomolgus/ Rhesus macaque RP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2307-Ab-1/ GM-Tg-felg-MP2307-Ab-2Anti-Feline RP2 monoclonal antibodyFeline
GM-Tg-cang-MP2307-Ab-1/ GM-Tg-cang-MP2307-Ab-2Anti-Canine RP2 monoclonal antibodyCanine
GM-Tg-bovg-MP2307-Ab-1/ GM-Tg-bovg-MP2307-Ab-2Anti-Bovine RP2 monoclonal antibodyBovine
GM-Tg-equg-MP2307-Ab-1/ GM-Tg-equg-MP2307-Ab-2Anti-Equine RP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2307-Ab-1/ GM-Tg-hg-MP2307-Ab-2; GM-Tg-rg-MP2307-Ab-1/ GM-Tg-rg-MP2307-Ab-2;
GM-Tg-mg-MP2307-Ab-1/ GM-Tg-mg-MP2307-Ab-2; GM-Tg-cynog-MP2307-Ab-1/ GM-Tg-cynog-MP2307-Ab-2;
GM-Tg-felg-MP2307-Ab-1/ GM-Tg-felg-MP2307-Ab-2; GM-Tg-cang-MP2307-Ab-1/ GM-Tg-cang-MP2307-Ab-2;
GM-Tg-bovg-MP2307-Ab-1/ GM-Tg-bovg-MP2307-Ab-2; GM-Tg-equg-MP2307-Ab-1/ GM-Tg-equg-MP2307-Ab-2
Products NameAnti-RP2 monoclonal antibody
Formatmab
Target NameRP2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species XRP2/ RP2/ DELXp11.3 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm002896mouse Rp2 Lentivirus plasmid
    ORF Viral VectorvGMLPm002896mouse Rp2 Lentivirus particle


    Target information

    Target IDGM-MP2307
    Target NameRP2
    Gene ID6102,19889,367714,711227,491853,101096879,534054,100060484
    Gene Symbol and SynonymsDELXp11.3,NM23-H10,NME10,RGD1565124,RP2,Rp2h,TBCCD2,XRP2
    Uniprot AccessionO75695
    Uniprot Entry NameXRP2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000102218
    Target ClassificationN/A

    The target: RP2, gene name: RP2, also named as DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2. The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.