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Anti-SI1L3/ SIPA1L3/ CTRCT45 monoclonal antibody
Anti-SI1L3/ SIPA1L3/ CTRCT45 antibody for FACS & in-vivo assay
Go to SIPA1L3/SIPA1L3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2327-Ab-1/ GM-Tg-hg-MP2327-Ab-2 | Anti-Human SIPA1L3 monoclonal antibody | Human |
| GM-Tg-rg-MP2327-Ab-1/ GM-Tg-rg-MP2327-Ab-2 | Anti-Rat SIPA1L3 monoclonal antibody | Rat |
| GM-Tg-mg-MP2327-Ab-1/ GM-Tg-mg-MP2327-Ab-2 | Anti-Mouse SIPA1L3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2327-Ab-1/ GM-Tg-cynog-MP2327-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SIPA1L3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2327-Ab-1/ GM-Tg-felg-MP2327-Ab-2 | Anti-Feline SIPA1L3 monoclonal antibody | Feline |
| GM-Tg-cang-MP2327-Ab-1/ GM-Tg-cang-MP2327-Ab-2 | Anti-Canine SIPA1L3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2327-Ab-1/ GM-Tg-bovg-MP2327-Ab-2 | Anti-Bovine SIPA1L3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2327-Ab-1/ GM-Tg-equg-MP2327-Ab-2 | Anti-Equine SIPA1L3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2327-Ab-1/ GM-Tg-hg-MP2327-Ab-2; GM-Tg-rg-MP2327-Ab-1/ GM-Tg-rg-MP2327-Ab-2; GM-Tg-mg-MP2327-Ab-1/ GM-Tg-mg-MP2327-Ab-2; GM-Tg-cynog-MP2327-Ab-1/ GM-Tg-cynog-MP2327-Ab-2; GM-Tg-felg-MP2327-Ab-1/ GM-Tg-felg-MP2327-Ab-2; GM-Tg-cang-MP2327-Ab-1/ GM-Tg-cang-MP2327-Ab-2; GM-Tg-bovg-MP2327-Ab-1/ GM-Tg-bovg-MP2327-Ab-2; GM-Tg-equg-MP2327-Ab-1/ GM-Tg-equg-MP2327-Ab-2 |
| Products Name | Anti-SIPA1L3 monoclonal antibody |
| Format | mab |
| Target Name | SIPA1L3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SIPA1L3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SI1L3/ SIPA1L3/ CTRCT45 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2327 |
| Target Name | SIPA1L3 |
| Gene ID | 23094,74206,292771,714601,612583,101096689,513625,100063981 |
| Gene Symbol and Synonyms | 2610511M17Rik,CTRCT45,SIPA1L3,SPAL3,SPAR3 |
| Uniprot Accession | O60292 |
| Uniprot Entry Name | SI1L3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105738 |
| Target Classification | N/A |
The target: SIPA1L3, gene name: SIPA1L3, also named as CTRCT45, SPAL3, SPAR3. This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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