Anti-SKAP1/ HEL-S-81p/ SCAP1 monoclonal antibody

Anti-SKAP1/ HEL-S-81p/ SCAP1 antibody for FACS & in-vivo assay

Target products collectionGo to SKAP1/SKAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2328-Ab-1/ GM-Tg-hg-MP2328-Ab-2Anti-Human SKAP1 monoclonal antibodyHuman
GM-Tg-rg-MP2328-Ab-1/ GM-Tg-rg-MP2328-Ab-2Anti-Rat SKAP1 monoclonal antibodyRat
GM-Tg-mg-MP2328-Ab-1/ GM-Tg-mg-MP2328-Ab-2Anti-Mouse SKAP1 monoclonal antibodyMouse
GM-Tg-cynog-MP2328-Ab-1/ GM-Tg-cynog-MP2328-Ab-2Anti-Cynomolgus/ Rhesus macaque SKAP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2328-Ab-1/ GM-Tg-felg-MP2328-Ab-2Anti-Feline SKAP1 monoclonal antibodyFeline
GM-Tg-cang-MP2328-Ab-1/ GM-Tg-cang-MP2328-Ab-2Anti-Canine SKAP1 monoclonal antibodyCanine
GM-Tg-bovg-MP2328-Ab-1/ GM-Tg-bovg-MP2328-Ab-2Anti-Bovine SKAP1 monoclonal antibodyBovine
GM-Tg-equg-MP2328-Ab-1/ GM-Tg-equg-MP2328-Ab-2Anti-Equine SKAP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2328-Ab-1/ GM-Tg-hg-MP2328-Ab-2; GM-Tg-rg-MP2328-Ab-1/ GM-Tg-rg-MP2328-Ab-2;
GM-Tg-mg-MP2328-Ab-1/ GM-Tg-mg-MP2328-Ab-2; GM-Tg-cynog-MP2328-Ab-1/ GM-Tg-cynog-MP2328-Ab-2;
GM-Tg-felg-MP2328-Ab-1/ GM-Tg-felg-MP2328-Ab-2; GM-Tg-cang-MP2328-Ab-1/ GM-Tg-cang-MP2328-Ab-2;
GM-Tg-bovg-MP2328-Ab-1/ GM-Tg-bovg-MP2328-Ab-2; GM-Tg-equg-MP2328-Ab-1/ GM-Tg-equg-MP2328-Ab-2
Products NameAnti-SKAP1 monoclonal antibody
Formatmab
Target NameSKAP1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SKAP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SKAP1/ HEL-S-81p/ SCAP1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2328
    Target NameSKAP1
    Gene ID8631,78473,286975,697043,480543,101096619,506769,100069371
    Gene Symbol and Synonyms1700091G21Rik,HEL-S-81p,SCAP1,Skap-55,SKAP1,SKAP55
    Uniprot AccessionQ86WV1,Q4V7G1
    Uniprot Entry NameSKAP1_HUMAN,SKAP1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000141293
    Target ClassificationN/A

    The target: SKAP1, gene name: SKAP1, also named as HEL-S-81p, SCAP1, SKAP55. This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.