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Anti-SNX15/ HSAF001435 monoclonal antibody
Anti-SNX15/ HSAF001435 antibody for FACS & in-vivo assay
Go to SNX15/SNX15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2333-Ab-1/ GM-Tg-hg-MP2333-Ab-2 | Anti-Human SNX15 monoclonal antibody | Human |
| GM-Tg-rg-MP2333-Ab-1/ GM-Tg-rg-MP2333-Ab-2 | Anti-Rat SNX15 monoclonal antibody | Rat |
| GM-Tg-mg-MP2333-Ab-1/ GM-Tg-mg-MP2333-Ab-2 | Anti-Mouse SNX15 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2333-Ab-1/ GM-Tg-cynog-MP2333-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SNX15 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2333-Ab-1/ GM-Tg-felg-MP2333-Ab-2 | Anti-Feline SNX15 monoclonal antibody | Feline |
| GM-Tg-cang-MP2333-Ab-1/ GM-Tg-cang-MP2333-Ab-2 | Anti-Canine SNX15 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2333-Ab-1/ GM-Tg-bovg-MP2333-Ab-2 | Anti-Bovine SNX15 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2333-Ab-1/ GM-Tg-equg-MP2333-Ab-2 | Anti-Equine SNX15 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2333-Ab-1/ GM-Tg-hg-MP2333-Ab-2; GM-Tg-rg-MP2333-Ab-1/ GM-Tg-rg-MP2333-Ab-2; GM-Tg-mg-MP2333-Ab-1/ GM-Tg-mg-MP2333-Ab-2; GM-Tg-cynog-MP2333-Ab-1/ GM-Tg-cynog-MP2333-Ab-2; GM-Tg-felg-MP2333-Ab-1/ GM-Tg-felg-MP2333-Ab-2; GM-Tg-cang-MP2333-Ab-1/ GM-Tg-cang-MP2333-Ab-2; GM-Tg-bovg-MP2333-Ab-1/ GM-Tg-bovg-MP2333-Ab-2; GM-Tg-equg-MP2333-Ab-1/ GM-Tg-equg-MP2333-Ab-2 |
| Products Name | Anti-SNX15 monoclonal antibody |
| Format | mab |
| Target Name | SNX15 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SNX15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SNX15/ HSAF001435 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2333 |
| Target Name | SNX15 |
| Gene ID | 29907,69024,293691,717071,612080,101082093,507751,100050811 |
| Gene Symbol and Synonyms | 1500032B08Rik,E130013C21Rik,HSAF001435,SNX15 |
| Uniprot Accession | Q9NRS6,Q4V896,Q148E7 |
| Uniprot Entry Name | SNX15_HUMAN,SNX15_RAT,SNX15_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000110025 |
| Target Classification | N/A |
The target: SNX15, gene name: SNX15, also named as HSAF001435. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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