Anti-SPTN2/ SPTBN2/ GTRAP41 monoclonal antibody

Anti-SPTN2/ SPTBN2/ GTRAP41 antibody for FACS & in-vivo assay

Target products collectionGo to SPTBN2/SPTBN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2336-Ab-1/ GM-Tg-hg-MP2336-Ab-2Anti-Human SPTBN2 monoclonal antibodyHuman
GM-Tg-rg-MP2336-Ab-1/ GM-Tg-rg-MP2336-Ab-2Anti-Rat SPTBN2 monoclonal antibodyRat
GM-Tg-mg-MP2336-Ab-1/ GM-Tg-mg-MP2336-Ab-2Anti-Mouse SPTBN2 monoclonal antibodyMouse
GM-Tg-cynog-MP2336-Ab-1/ GM-Tg-cynog-MP2336-Ab-2Anti-Cynomolgus/ Rhesus macaque SPTBN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2336-Ab-1/ GM-Tg-felg-MP2336-Ab-2Anti-Feline SPTBN2 monoclonal antibodyFeline
GM-Tg-cang-MP2336-Ab-1/ GM-Tg-cang-MP2336-Ab-2Anti-Canine SPTBN2 monoclonal antibodyCanine
GM-Tg-bovg-MP2336-Ab-1/ GM-Tg-bovg-MP2336-Ab-2Anti-Bovine SPTBN2 monoclonal antibodyBovine
GM-Tg-equg-MP2336-Ab-1/ GM-Tg-equg-MP2336-Ab-2Anti-Equine SPTBN2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2336-Ab-1/ GM-Tg-hg-MP2336-Ab-2; GM-Tg-rg-MP2336-Ab-1/ GM-Tg-rg-MP2336-Ab-2;
GM-Tg-mg-MP2336-Ab-1/ GM-Tg-mg-MP2336-Ab-2; GM-Tg-cynog-MP2336-Ab-1/ GM-Tg-cynog-MP2336-Ab-2;
GM-Tg-felg-MP2336-Ab-1/ GM-Tg-felg-MP2336-Ab-2; GM-Tg-cang-MP2336-Ab-1/ GM-Tg-cang-MP2336-Ab-2;
GM-Tg-bovg-MP2336-Ab-1/ GM-Tg-bovg-MP2336-Ab-2; GM-Tg-equg-MP2336-Ab-1/ GM-Tg-equg-MP2336-Ab-2
Products NameAnti-SPTBN2 monoclonal antibody
Formatmab
Target NameSPTBN2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPTBN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPTN2/ SPTBN2/ GTRAP41 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2336
    Target NameSPTBN2
    Gene ID6712,20743,29211,713419,483706,101089045,100052745
    Gene Symbol and SynonymsGTRAP41,SCA5,SCAR14,Spnb3,SPTBN2
    Uniprot AccessionO15020,Q9QWN8
    Uniprot Entry NameSPTN2_HUMAN,SPTN2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000173898
    Target ClassificationN/A

    The target: SPTBN2, gene name: SPTBN2, also named as GTRAP41, SCA5, SCAR14. Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.