Anti-STK10/ LOK/ PRO2729 monoclonal antibody

Anti-STK10/ LOK/ PRO2729 antibody for FACS & in-vivo assay

Target products collectionGo to STK10/STK10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2340-Ab-1/ GM-Tg-hg-MP2340-Ab-2Anti-Human STK10 monoclonal antibodyHuman
GM-Tg-rg-MP2340-Ab-1/ GM-Tg-rg-MP2340-Ab-2Anti-Rat STK10 monoclonal antibodyRat
GM-Tg-mg-MP2340-Ab-1/ GM-Tg-mg-MP2340-Ab-2Anti-Mouse STK10 monoclonal antibodyMouse
GM-Tg-cynog-MP2340-Ab-1/ GM-Tg-cynog-MP2340-Ab-2Anti-Cynomolgus/ Rhesus macaque STK10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2340-Ab-1/ GM-Tg-felg-MP2340-Ab-2Anti-Feline STK10 monoclonal antibodyFeline
GM-Tg-cang-MP2340-Ab-1/ GM-Tg-cang-MP2340-Ab-2Anti-Canine STK10 monoclonal antibodyCanine
GM-Tg-bovg-MP2340-Ab-1/ GM-Tg-bovg-MP2340-Ab-2Anti-Bovine STK10 monoclonal antibodyBovine
GM-Tg-equg-MP2340-Ab-1/ GM-Tg-equg-MP2340-Ab-2Anti-Equine STK10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2340-Ab-1/ GM-Tg-hg-MP2340-Ab-2; GM-Tg-rg-MP2340-Ab-1/ GM-Tg-rg-MP2340-Ab-2;
GM-Tg-mg-MP2340-Ab-1/ GM-Tg-mg-MP2340-Ab-2; GM-Tg-cynog-MP2340-Ab-1/ GM-Tg-cynog-MP2340-Ab-2;
GM-Tg-felg-MP2340-Ab-1/ GM-Tg-felg-MP2340-Ab-2; GM-Tg-cang-MP2340-Ab-1/ GM-Tg-cang-MP2340-Ab-2;
GM-Tg-bovg-MP2340-Ab-1/ GM-Tg-bovg-MP2340-Ab-2; GM-Tg-equg-MP2340-Ab-1/ GM-Tg-equg-MP2340-Ab-2
Products NameAnti-STK10 monoclonal antibody
Formatmab
Target NameSTK10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-STK10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species STK10/ LOK/ PRO2729 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2340
    Target NameSTK10
    Gene ID6793,20868,29398,702402,489121,101098281,526376,100069956
    Gene Symbol and SynonymsGek1,LOK,mKIAA4026,PRO2729,STK10
    Uniprot AccessionO94804,E9PTG8,E1BK52
    Uniprot Entry NameSTK10_HUMAN,STK10_RAT,STK10_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000072786
    Target ClassificationKinase

    The target: STK10, gene name: STK10, also named as LOK, PRO2729. This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.