Anti-TBC24/ TBC1D24/ DFNA65 monoclonal antibody

Anti-TBC24/ TBC1D24/ DFNA65 antibody for FACS & in-vivo assay

Target products collectionGo to TBC1D24/TBC1D24 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2347-Ab-1/ GM-Tg-hg-MP2347-Ab-2Anti-Human TBC1D24 monoclonal antibodyHuman
GM-Tg-rg-MP2347-Ab-1/ GM-Tg-rg-MP2347-Ab-2Anti-Rat TBC1D24 monoclonal antibodyRat
GM-Tg-mg-MP2347-Ab-1/ GM-Tg-mg-MP2347-Ab-2Anti-Mouse TBC1D24 monoclonal antibodyMouse
GM-Tg-cynog-MP2347-Ab-1/ GM-Tg-cynog-MP2347-Ab-2Anti-Cynomolgus/ Rhesus macaque TBC1D24 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2347-Ab-1/ GM-Tg-felg-MP2347-Ab-2Anti-Feline TBC1D24 monoclonal antibodyFeline
GM-Tg-cang-MP2347-Ab-1/ GM-Tg-cang-MP2347-Ab-2Anti-Canine TBC1D24 monoclonal antibodyCanine
GM-Tg-bovg-MP2347-Ab-1/ GM-Tg-bovg-MP2347-Ab-2Anti-Bovine TBC1D24 monoclonal antibodyBovine
GM-Tg-equg-MP2347-Ab-1/ GM-Tg-equg-MP2347-Ab-2Anti-Equine TBC1D24 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2347-Ab-1/ GM-Tg-hg-MP2347-Ab-2; GM-Tg-rg-MP2347-Ab-1/ GM-Tg-rg-MP2347-Ab-2;
GM-Tg-mg-MP2347-Ab-1/ GM-Tg-mg-MP2347-Ab-2; GM-Tg-cynog-MP2347-Ab-1/ GM-Tg-cynog-MP2347-Ab-2;
GM-Tg-felg-MP2347-Ab-1/ GM-Tg-felg-MP2347-Ab-2; GM-Tg-cang-MP2347-Ab-1/ GM-Tg-cang-MP2347-Ab-2;
GM-Tg-bovg-MP2347-Ab-1/ GM-Tg-bovg-MP2347-Ab-2; GM-Tg-equg-MP2347-Ab-1/ GM-Tg-equg-MP2347-Ab-2
Products NameAnti-TBC1D24 monoclonal antibody
Formatmab
Target NameTBC1D24
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TBC1D24 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TBC24/ TBC1D24/ DFNA65 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2347
    Target NameTBC1D24
    Gene ID57465,224617,287110,697106,609726,101101685,529002,100065761
    Gene Symbol and Synonyms9630033P11,C530046L02Rik,DEE16,DFNA65,DFNB86,DOORS,EIEE16,EIM,EPRPDC,FIME,mKIAA1171,RGD1306143,TBC1D24,TLDC6
    Uniprot AccessionQ9ULP9,Q29RJ2
    Uniprot Entry NameTBC24_HUMAN,TBC24_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000162065
    Target ClassificationN/A

    The target: TBC1D24, gene name: TBC1D24, also named as DFNA65, DFNB86, DOORS, EIEE16, FIME, TLDC6. This gene encodes a protein with a conserved domain, referred to as the TBC domain, characteristic of proteins which interact with GTPases. TBC domain proteins may serve as GTPase-activating proteins for a particular group of GTPases, the Rab (Ras-related proteins in brain) small GTPases which are involved in the regulation of membrane trafficking. Mutations in this gene are associated with familial infantile myoclonic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.