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Anti-TCIM/ C8orf4/ TC-1 monoclonal antibody
Anti-TCIM/ C8orf4/ TC-1 antibody for FACS & in-vivo assay
Go to TCIM/TCIM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2351-Ab-1/ GM-Tg-hg-MP2351-Ab-2 | Anti-Human TCIM monoclonal antibody | Human |
| GM-Tg-rg-MP2351-Ab-1/ GM-Tg-rg-MP2351-Ab-2 | Anti-Rat TCIM monoclonal antibody | Rat |
| GM-Tg-mg-MP2351-Ab-1/ GM-Tg-mg-MP2351-Ab-2 | Anti-Mouse TCIM monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2351-Ab-1/ GM-Tg-cynog-MP2351-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TCIM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2351-Ab-1/ GM-Tg-felg-MP2351-Ab-2 | Anti-Feline TCIM monoclonal antibody | Feline |
| GM-Tg-cang-MP2351-Ab-1/ GM-Tg-cang-MP2351-Ab-2 | Anti-Canine TCIM monoclonal antibody | Canine |
| GM-Tg-bovg-MP2351-Ab-1/ GM-Tg-bovg-MP2351-Ab-2 | Anti-Bovine TCIM monoclonal antibody | Bovine |
| GM-Tg-equg-MP2351-Ab-1/ GM-Tg-equg-MP2351-Ab-2 | Anti-Equine TCIM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2351-Ab-1/ GM-Tg-hg-MP2351-Ab-2; GM-Tg-rg-MP2351-Ab-1/ GM-Tg-rg-MP2351-Ab-2; GM-Tg-mg-MP2351-Ab-1/ GM-Tg-mg-MP2351-Ab-2; GM-Tg-cynog-MP2351-Ab-1/ GM-Tg-cynog-MP2351-Ab-2; GM-Tg-felg-MP2351-Ab-1/ GM-Tg-felg-MP2351-Ab-2; GM-Tg-cang-MP2351-Ab-1/ GM-Tg-cang-MP2351-Ab-2; GM-Tg-bovg-MP2351-Ab-1/ GM-Tg-bovg-MP2351-Ab-2; GM-Tg-equg-MP2351-Ab-1/ GM-Tg-equg-MP2351-Ab-2 |
| Products Name | Anti-TCIM monoclonal antibody |
| Format | mab |
| Target Name | TCIM |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TCIM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TCIM/ C8orf4/ TC-1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2351 |
| Target Name | TCIM |
| Gene ID | 56892,69068,684871,702517,607623,101084103,617047,100050602 |
| Gene Symbol and Synonyms | 1110065B09Rik,1810011O10Rik,C16H8orf4,C27H8orf4,C8H8orf4,C8orf4,CB1H8orf4,TC-1,TC1,TCIM |
| Uniprot Accession | Q9NR00,Q5E969 |
| Uniprot Entry Name | TCIM_HUMAN,TCIM_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000176907 |
| Target Classification | N/A |
The target: TCIM, gene name: TCIM, also named as C8orf4, TC-1, TC1. This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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