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Anti-ZO2/ TJP2/ C9DUPq21.11 monoclonal antibody
Anti-ZO2/ TJP2/ C9DUPq21.11 antibody for FACS & in-vivo assay
Go to TJP2/TJP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2354-Ab-1/ GM-Tg-hg-MP2354-Ab-2 | Anti-Human TJP2 monoclonal antibody | Human |
| GM-Tg-rg-MP2354-Ab-1/ GM-Tg-rg-MP2354-Ab-2 | Anti-Rat TJP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2354-Ab-1/ GM-Tg-mg-MP2354-Ab-2 | Anti-Mouse TJP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2354-Ab-1/ GM-Tg-cynog-MP2354-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TJP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2354-Ab-1/ GM-Tg-felg-MP2354-Ab-2 | Anti-Feline TJP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2354-Ab-1/ GM-Tg-cang-MP2354-Ab-2 | Anti-Canine TJP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2354-Ab-1/ GM-Tg-bovg-MP2354-Ab-2 | Anti-Bovine TJP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2354-Ab-1/ GM-Tg-equg-MP2354-Ab-2 | Anti-Equine TJP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2354-Ab-1/ GM-Tg-hg-MP2354-Ab-2; GM-Tg-rg-MP2354-Ab-1/ GM-Tg-rg-MP2354-Ab-2; GM-Tg-mg-MP2354-Ab-1/ GM-Tg-mg-MP2354-Ab-2; GM-Tg-cynog-MP2354-Ab-1/ GM-Tg-cynog-MP2354-Ab-2; GM-Tg-felg-MP2354-Ab-1/ GM-Tg-felg-MP2354-Ab-2; GM-Tg-cang-MP2354-Ab-1/ GM-Tg-cang-MP2354-Ab-2; GM-Tg-bovg-MP2354-Ab-1/ GM-Tg-bovg-MP2354-Ab-2; GM-Tg-equg-MP2354-Ab-1/ GM-Tg-equg-MP2354-Ab-2 |
| Products Name | Anti-TJP2 monoclonal antibody |
| Format | mab |
| Target Name | TJP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TJP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ZO2/ TJP2/ C9DUPq21.11 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2354 |
| Target Name | TJP2 |
| Gene ID | 9414,21873,115769,699586,403854,101081681,407101,100050442 |
| Gene Symbol and Synonyms | C9DUPq21.11,DFNA51,DUP9q21.11,FHCA1,PFIC4,TJP2,X104,ZO-2,ZO2 |
| Uniprot Accession | Q9UDY2,Q95168 |
| Uniprot Entry Name | ZO2_HUMAN,ZO2_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000119139 |
| Target Classification | N/A |
The target: TJP2, gene name: TJP2, also named as C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2. This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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