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Anti-TLN1/ ILWEQ/ TLN monoclonal antibody
Anti-TLN1/ ILWEQ/ TLN antibody for FACS & in-vivo assay
Go to TLN1/TLN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2356-Ab-1/ GM-Tg-hg-MP2356-Ab-2 | Anti-Human TLN1 monoclonal antibody | Human |
| GM-Tg-rg-MP2356-Ab-1/ GM-Tg-rg-MP2356-Ab-2 | Anti-Rat TLN1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2356-Ab-1/ GM-Tg-mg-MP2356-Ab-2 | Anti-Mouse TLN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2356-Ab-1/ GM-Tg-cynog-MP2356-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TLN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2356-Ab-1/ GM-Tg-felg-MP2356-Ab-2 | Anti-Feline TLN1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2356-Ab-1/ GM-Tg-cang-MP2356-Ab-2 | Anti-Canine TLN1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2356-Ab-1/ GM-Tg-bovg-MP2356-Ab-2 | Anti-Bovine TLN1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2356-Ab-1/ GM-Tg-equg-MP2356-Ab-2 | Anti-Equine TLN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2356-Ab-1/ GM-Tg-hg-MP2356-Ab-2; GM-Tg-rg-MP2356-Ab-1/ GM-Tg-rg-MP2356-Ab-2; GM-Tg-mg-MP2356-Ab-1/ GM-Tg-mg-MP2356-Ab-2; GM-Tg-cynog-MP2356-Ab-1/ GM-Tg-cynog-MP2356-Ab-2; GM-Tg-felg-MP2356-Ab-1/ GM-Tg-felg-MP2356-Ab-2; GM-Tg-cang-MP2356-Ab-1/ GM-Tg-cang-MP2356-Ab-2; GM-Tg-bovg-MP2356-Ab-1/ GM-Tg-bovg-MP2356-Ab-2; GM-Tg-equg-MP2356-Ab-1/ GM-Tg-equg-MP2356-Ab-2 |
| Products Name | Anti-TLN1 monoclonal antibody |
| Format | mab |
| Target Name | TLN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TLN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TLN1/ ILWEQ/ TLN VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2356 |
| Target Name | TLN1 |
| Gene ID | 7094,21894,313494,696298,100856393,101093057,783470,100055501 |
| Gene Symbol and Synonyms | ILWEQ,talin-1,TLN,TLN1 |
| Uniprot Accession | Q9Y490 |
| Uniprot Entry Name | TLN1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Mucocutaneous lymph node syndrome [Kawasaki] |
| Gene Ensembl | ENSG00000137076 |
| Target Classification | N/A |
The target: TLN1, gene name: TLN1, also named as ILWEQ, TLN, talin-1. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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