Anti-TSH3/ TSHZ3/ ZNF537 monoclonal antibody

Anti-TSH3/ TSHZ3/ ZNF537 antibody for FACS & in-vivo assay

Target products collectionGo to TSHZ3/TSHZ3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2363-Ab-1/ GM-Tg-hg-MP2363-Ab-2Anti-Human TSHZ3 monoclonal antibodyHuman
GM-Tg-rg-MP2363-Ab-1/ GM-Tg-rg-MP2363-Ab-2Anti-Rat TSHZ3 monoclonal antibodyRat
GM-Tg-mg-MP2363-Ab-1/ GM-Tg-mg-MP2363-Ab-2Anti-Mouse TSHZ3 monoclonal antibodyMouse
GM-Tg-cynog-MP2363-Ab-1/ GM-Tg-cynog-MP2363-Ab-2Anti-Cynomolgus/ Rhesus macaque TSHZ3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2363-Ab-1/ GM-Tg-felg-MP2363-Ab-2Anti-Feline TSHZ3 monoclonal antibodyFeline
GM-Tg-cang-MP2363-Ab-1/ GM-Tg-cang-MP2363-Ab-2Anti-Canine TSHZ3 monoclonal antibodyCanine
GM-Tg-bovg-MP2363-Ab-1/ GM-Tg-bovg-MP2363-Ab-2Anti-Bovine TSHZ3 monoclonal antibodyBovine
GM-Tg-equg-MP2363-Ab-1/ GM-Tg-equg-MP2363-Ab-2Anti-Equine TSHZ3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2363-Ab-1/ GM-Tg-hg-MP2363-Ab-2; GM-Tg-rg-MP2363-Ab-1/ GM-Tg-rg-MP2363-Ab-2;
GM-Tg-mg-MP2363-Ab-1/ GM-Tg-mg-MP2363-Ab-2; GM-Tg-cynog-MP2363-Ab-1/ GM-Tg-cynog-MP2363-Ab-2;
GM-Tg-felg-MP2363-Ab-1/ GM-Tg-felg-MP2363-Ab-2; GM-Tg-cang-MP2363-Ab-1/ GM-Tg-cang-MP2363-Ab-2;
GM-Tg-bovg-MP2363-Ab-1/ GM-Tg-bovg-MP2363-Ab-2; GM-Tg-equg-MP2363-Ab-1/ GM-Tg-equg-MP2363-Ab-2
Products NameAnti-TSHZ3 monoclonal antibody
Formatmab
Target NameTSHZ3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TSHZ3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TSH3/ TSHZ3/ ZNF537 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2363
    Target NameTSHZ3
    Gene ID57616,243931,308523,714189,484607,101085421,540209,100054683
    Gene Symbol and SynonymsA630038G13Rik,mKIAA1474,teashirt3,TSH3,TSHZ3,Zfp537,ZNF537
    Uniprot AccessionQ63HK5,D3ZKB9
    Uniprot Entry NameTSH3_HUMAN,TSH3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000121297
    Target ClassificationN/A

    The target: TSHZ3, gene name: TSHZ3, also named as TSH3, ZNF537. This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.