Anti-UBQL2/ UBQLN2/ ALS15 monoclonal antibody

Anti-UBQL2/ UBQLN2/ ALS15 antibody for FACS & in-vivo assay

Target products collectionGo to UBQLN2/UBQLN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2375-Ab-1/ GM-Tg-hg-MP2375-Ab-2Anti-Human UBQLN2 monoclonal antibodyHuman
GM-Tg-rg-MP2375-Ab-1/ GM-Tg-rg-MP2375-Ab-2Anti-Rat UBQLN2 monoclonal antibodyRat
GM-Tg-mg-MP2375-Ab-1/ GM-Tg-mg-MP2375-Ab-2Anti-Mouse UBQLN2 monoclonal antibodyMouse
GM-Tg-cynog-MP2375-Ab-1/ GM-Tg-cynog-MP2375-Ab-2Anti-Cynomolgus/ Rhesus macaque UBQLN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2375-Ab-1/ GM-Tg-felg-MP2375-Ab-2Anti-Feline UBQLN2 monoclonal antibodyFeline
GM-Tg-cang-MP2375-Ab-1/ GM-Tg-cang-MP2375-Ab-2Anti-Canine UBQLN2 monoclonal antibodyCanine
GM-Tg-bovg-MP2375-Ab-1/ GM-Tg-bovg-MP2375-Ab-2Anti-Bovine UBQLN2 monoclonal antibodyBovine
GM-Tg-equg-MP2375-Ab-1/ GM-Tg-equg-MP2375-Ab-2Anti-Equine UBQLN2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2375-Ab-1/ GM-Tg-hg-MP2375-Ab-2; GM-Tg-rg-MP2375-Ab-1/ GM-Tg-rg-MP2375-Ab-2;
GM-Tg-mg-MP2375-Ab-1/ GM-Tg-mg-MP2375-Ab-2; GM-Tg-cynog-MP2375-Ab-1/ GM-Tg-cynog-MP2375-Ab-2;
GM-Tg-felg-MP2375-Ab-1/ GM-Tg-felg-MP2375-Ab-2; GM-Tg-cang-MP2375-Ab-1/ GM-Tg-cang-MP2375-Ab-2;
GM-Tg-bovg-MP2375-Ab-1/ GM-Tg-bovg-MP2375-Ab-2; GM-Tg-equg-MP2375-Ab-1/ GM-Tg-equg-MP2375-Ab-2
Products NameAnti-UBQLN2 monoclonal antibody
Formatmab
Target NameUBQLN2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-UBQLN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species UBQL2/ UBQLN2/ ALS15 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2375
    Target NameUBQLN2
    Gene ID29978,54609,317396,707967,491909,101097874,539529,100050402
    Gene Symbol and SynonymsALS15,CHAP1,DSK2,HRIHFB2157,N4BP4,Plic-2,PLIC2,RGD1563566,UBQLN2
    Uniprot AccessionQ9UHD9
    Uniprot Entry NameUBQL2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000188021
    Target ClassificationN/A

    The target: UBQLN2, gene name: UBQLN2, also named as ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2. This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.