Anti-FRITZ/ WDPCP/ BBS15 monoclonal antibody

Anti-FRITZ/ WDPCP/ BBS15 antibody for FACS & in-vivo assay

Target products collectionGo to WDPCP/WDPCP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2383-Ab-1/ GM-Tg-hg-MP2383-Ab-2Anti-Human WDPCP monoclonal antibodyHuman
GM-Tg-rg-MP2383-Ab-1/ GM-Tg-rg-MP2383-Ab-2Anti-Rat WDPCP monoclonal antibodyRat
GM-Tg-mg-MP2383-Ab-1/ GM-Tg-mg-MP2383-Ab-2Anti-Mouse WDPCP monoclonal antibodyMouse
GM-Tg-cynog-MP2383-Ab-1/ GM-Tg-cynog-MP2383-Ab-2Anti-Cynomolgus/ Rhesus macaque WDPCP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2383-Ab-1/ GM-Tg-felg-MP2383-Ab-2Anti-Feline WDPCP monoclonal antibodyFeline
GM-Tg-cang-MP2383-Ab-1/ GM-Tg-cang-MP2383-Ab-2Anti-Canine WDPCP monoclonal antibodyCanine
GM-Tg-bovg-MP2383-Ab-1/ GM-Tg-bovg-MP2383-Ab-2Anti-Bovine WDPCP monoclonal antibodyBovine
GM-Tg-equg-MP2383-Ab-1/ GM-Tg-equg-MP2383-Ab-2Anti-Equine WDPCP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2383-Ab-1/ GM-Tg-hg-MP2383-Ab-2; GM-Tg-rg-MP2383-Ab-1/ GM-Tg-rg-MP2383-Ab-2;
GM-Tg-mg-MP2383-Ab-1/ GM-Tg-mg-MP2383-Ab-2; GM-Tg-cynog-MP2383-Ab-1/ GM-Tg-cynog-MP2383-Ab-2;
GM-Tg-felg-MP2383-Ab-1/ GM-Tg-felg-MP2383-Ab-2; GM-Tg-cang-MP2383-Ab-1/ GM-Tg-cang-MP2383-Ab-2;
GM-Tg-bovg-MP2383-Ab-1/ GM-Tg-bovg-MP2383-Ab-2; GM-Tg-equg-MP2383-Ab-1/ GM-Tg-equg-MP2383-Ab-2
Products NameAnti-WDPCP monoclonal antibody
Formatmab
Target NameWDPCP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-WDPCP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species FRITZ/ WDPCP/ BBS15 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2383
    Target NameWDPCP
    Gene ID51057,216560,305552,694431,474613,101085794,527992,100063987
    Gene Symbol and SynonymsBBS15,C2orf86,CHDTHP,CPLANE5,FRITZ,FRTZ,homolog-13,RGD1309501,WDPCP
    Uniprot AccessionO95876,B1WC10
    Uniprot Entry NameFRITZ_HUMAN,FRITZ_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000143951
    Target ClassificationN/A

    The target: WDPCP, gene name: WDPCP, also named as BBS15, C2orf86, CHDTHP, CPLANE5, FRITZ, FRTZ. This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.