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Anti-XPC/ RAD4/ XP3C monoclonal antibody
Anti-XPC/ RAD4/ XP3C antibody for FACS & in-vivo assay
Go to XPC/XPC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2387-Ab-1/ GM-Tg-hg-MP2387-Ab-2 | Anti-Human XPC monoclonal antibody | Human |
| GM-Tg-rg-MP2387-Ab-1/ GM-Tg-rg-MP2387-Ab-2 | Anti-Rat XPC monoclonal antibody | Rat |
| GM-Tg-mg-MP2387-Ab-1/ GM-Tg-mg-MP2387-Ab-2 | Anti-Mouse XPC monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2387-Ab-1/ GM-Tg-cynog-MP2387-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XPC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2387-Ab-1/ GM-Tg-felg-MP2387-Ab-2 | Anti-Feline XPC monoclonal antibody | Feline |
| GM-Tg-cang-MP2387-Ab-1/ GM-Tg-cang-MP2387-Ab-2 | Anti-Canine XPC monoclonal antibody | Canine |
| GM-Tg-bovg-MP2387-Ab-1/ GM-Tg-bovg-MP2387-Ab-2 | Anti-Bovine XPC monoclonal antibody | Bovine |
| GM-Tg-equg-MP2387-Ab-1/ GM-Tg-equg-MP2387-Ab-2 | Anti-Equine XPC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2387-Ab-1/ GM-Tg-hg-MP2387-Ab-2; GM-Tg-rg-MP2387-Ab-1/ GM-Tg-rg-MP2387-Ab-2; GM-Tg-mg-MP2387-Ab-1/ GM-Tg-mg-MP2387-Ab-2; GM-Tg-cynog-MP2387-Ab-1/ GM-Tg-cynog-MP2387-Ab-2; GM-Tg-felg-MP2387-Ab-1/ GM-Tg-felg-MP2387-Ab-2; GM-Tg-cang-MP2387-Ab-1/ GM-Tg-cang-MP2387-Ab-2; GM-Tg-bovg-MP2387-Ab-1/ GM-Tg-bovg-MP2387-Ab-2; GM-Tg-equg-MP2387-Ab-1/ GM-Tg-equg-MP2387-Ab-2 |
| Products Name | Anti-XPC monoclonal antibody |
| Format | mab |
| Target Name | XPC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-XPC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species XPC/ RAD4/ XP3C VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2387 |
| Target Name | XPC |
| Gene ID | 7508,22591,312560,700938,476521,101080440,524274,100050424 |
| Gene Symbol and Synonyms | p125,RAD4,XP3,XPC,XPCC |
| Uniprot Accession | Q01831 |
| Uniprot Entry Name | XPC_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000154767 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: XPC, gene name: XPC, also named as RAD4, XP3C, p125, XPC. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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