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Anti-NLRP6/ AVR/ CLR11.4 monoclonal antibody
Anti-NLRP6/ AVR/ CLR11.4 antibody for FACS & in-vivo assay
Go to NLRP6/NLRP6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2400-Ab-1/ GM-Tg-hg-MP2400-Ab-2 | Anti-Human NLRP6 monoclonal antibody | Human |
| GM-Tg-rg-MP2400-Ab-1/ GM-Tg-rg-MP2400-Ab-2 | Anti-Rat NLRP6 monoclonal antibody | Rat |
| GM-Tg-mg-MP2400-Ab-1/ GM-Tg-mg-MP2400-Ab-2 | Anti-Mouse NLRP6 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2400-Ab-1/ GM-Tg-cynog-MP2400-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NLRP6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2400-Ab-1/ GM-Tg-felg-MP2400-Ab-2 | Anti-Feline NLRP6 monoclonal antibody | Feline |
| GM-Tg-cang-MP2400-Ab-1/ GM-Tg-cang-MP2400-Ab-2 | Anti-Canine NLRP6 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2400-Ab-1/ GM-Tg-bovg-MP2400-Ab-2 | Anti-Bovine NLRP6 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2400-Ab-1/ GM-Tg-equg-MP2400-Ab-2 | Anti-Equine NLRP6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2400-Ab-1/ GM-Tg-hg-MP2400-Ab-2; GM-Tg-rg-MP2400-Ab-1/ GM-Tg-rg-MP2400-Ab-2; GM-Tg-mg-MP2400-Ab-1/ GM-Tg-mg-MP2400-Ab-2; GM-Tg-cynog-MP2400-Ab-1/ GM-Tg-cynog-MP2400-Ab-2; GM-Tg-felg-MP2400-Ab-1/ GM-Tg-felg-MP2400-Ab-2; GM-Tg-cang-MP2400-Ab-1/ GM-Tg-cang-MP2400-Ab-2; GM-Tg-bovg-MP2400-Ab-1/ GM-Tg-bovg-MP2400-Ab-2; GM-Tg-equg-MP2400-Ab-1/ GM-Tg-equg-MP2400-Ab-2 |
| Products Name | Anti-NLRP6 monoclonal antibody |
| Format | mab |
| Target Name | NLRP6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NLRP6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NLRP6/ AVR/ CLR11.4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001699 | human NLRP6 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001699 | human NLRP6 Lentivirus particle |
Target information
| Target ID | GM-MP2400 |
| Target Name | NLRP6 |
| Gene ID | 171389,101613,171390,720741,483394,101087351,505101,100146460 |
| Gene Symbol and Synonyms | AVR,CLR11.4,NALP6,NAVR,NAVR/AVR,NLRP6,Non-AVR,PAN3,PYPAF5 |
| Uniprot Accession | P59044,Q63035 |
| Uniprot Entry Name | NLRP6_HUMAN,NLRP6_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000174885 |
| Target Classification | N/A |
The target: NLRP6, gene name: NLRP6, also named as AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5. The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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