Anti-CO4B/ C4B/ C4B112 monoclonal antibody

Anti-CO4B/ C4B/ C4B112 antibody for FACS & in-vivo assay

Target products collectionGo to C4B/C4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2420-Ab-1/ GM-Tg-hg-MP2420-Ab-2Anti-Human C4B monoclonal antibodyHuman
GM-Tg-rg-MP2420-Ab-1/ GM-Tg-rg-MP2420-Ab-2Anti-Rat C4B monoclonal antibodyRat
GM-Tg-mg-MP2420-Ab-1/ GM-Tg-mg-MP2420-Ab-2Anti-Mouse C4B monoclonal antibodyMouse
GM-Tg-cynog-MP2420-Ab-1/ GM-Tg-cynog-MP2420-Ab-2Anti-Cynomolgus/ Rhesus macaque C4B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2420-Ab-1/ GM-Tg-felg-MP2420-Ab-2Anti-Feline C4B monoclonal antibodyFeline
GM-Tg-cang-MP2420-Ab-1/ GM-Tg-cang-MP2420-Ab-2Anti-Canine C4B monoclonal antibodyCanine
GM-Tg-bovg-MP2420-Ab-1/ GM-Tg-bovg-MP2420-Ab-2Anti-Bovine C4B monoclonal antibodyBovine
GM-Tg-equg-MP2420-Ab-1/ GM-Tg-equg-MP2420-Ab-2Anti-Equine C4B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2420-Ab-1/ GM-Tg-hg-MP2420-Ab-2; GM-Tg-rg-MP2420-Ab-1/ GM-Tg-rg-MP2420-Ab-2;
GM-Tg-mg-MP2420-Ab-1/ GM-Tg-mg-MP2420-Ab-2; GM-Tg-cynog-MP2420-Ab-1/ GM-Tg-cynog-MP2420-Ab-2;
GM-Tg-felg-MP2420-Ab-1/ GM-Tg-felg-MP2420-Ab-2; GM-Tg-cang-MP2420-Ab-1/ GM-Tg-cang-MP2420-Ab-2;
GM-Tg-bovg-MP2420-Ab-1/ GM-Tg-bovg-MP2420-Ab-2; GM-Tg-equg-MP2420-Ab-1/ GM-Tg-equg-MP2420-Ab-2
Products NameAnti-C4B monoclonal antibody
Formatmab
Target NameC4B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-C4B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-813Pre-Made Efdamrofusp Alfa P Alfaiosimilar, Bispecific, Anti-C3/CO3;C4B;VEGFA Antibody: Anti-AHUS5/ARMD9/ASP/CPAMD1/HEL-S-62p;CH/C4F/CO4/C4BD/C4B12/CPAMD3;VPF/MVCD1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CO4B/ C4B/ C4B112 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2420
    Target NameC4B
    Gene ID721
    Gene Symbol and SynonymsC4B,C4B1,C4B12,C4B2,C4B3,C4B5,C4BD,C4B_2,C4F,CH,CO4,CPAMD3
    Uniprot AccessionP0C0L5
    Uniprot Entry NameCO4B_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseMalignant neoplasm of bladder
    Gene EnsemblENSG00000224389
    Target ClassificationN/A

    The target: C4B, gene name: C4B, also named as C4B112, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3, C4B. This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, May 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.