Anti-CO6/ C6 monoclonal antibody

Anti-CO6/ C6 antibody for FACS & in-vivo assay

Target products collectionGo to C6/C6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2421-Ab-1/ GM-Tg-hg-MP2421-Ab-2Anti-Human C6 monoclonal antibodyHuman
GM-Tg-rg-MP2421-Ab-1/ GM-Tg-rg-MP2421-Ab-2Anti-Rat C6 monoclonal antibodyRat
GM-Tg-mg-MP2421-Ab-1/ GM-Tg-mg-MP2421-Ab-2Anti-Mouse C6 monoclonal antibodyMouse
GM-Tg-cynog-MP2421-Ab-1/ GM-Tg-cynog-MP2421-Ab-2Anti-Cynomolgus/ Rhesus macaque C6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2421-Ab-1/ GM-Tg-felg-MP2421-Ab-2Anti-Feline C6 monoclonal antibodyFeline
GM-Tg-cang-MP2421-Ab-1/ GM-Tg-cang-MP2421-Ab-2Anti-Canine C6 monoclonal antibodyCanine
GM-Tg-bovg-MP2421-Ab-1/ GM-Tg-bovg-MP2421-Ab-2Anti-Bovine C6 monoclonal antibodyBovine
GM-Tg-equg-MP2421-Ab-1/ GM-Tg-equg-MP2421-Ab-2Anti-Equine C6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2421-Ab-1/ GM-Tg-hg-MP2421-Ab-2; GM-Tg-rg-MP2421-Ab-1/ GM-Tg-rg-MP2421-Ab-2;
GM-Tg-mg-MP2421-Ab-1/ GM-Tg-mg-MP2421-Ab-2; GM-Tg-cynog-MP2421-Ab-1/ GM-Tg-cynog-MP2421-Ab-2;
GM-Tg-felg-MP2421-Ab-1/ GM-Tg-felg-MP2421-Ab-2; GM-Tg-cang-MP2421-Ab-1/ GM-Tg-cang-MP2421-Ab-2;
GM-Tg-bovg-MP2421-Ab-1/ GM-Tg-bovg-MP2421-Ab-2; GM-Tg-equg-MP2421-Ab-1/ GM-Tg-equg-MP2421-Ab-2
Products NameAnti-C6 monoclonal antibody
Formatmab
Target NameC6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-C6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CO6/ C6 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2421
    Target NameC6
    Gene ID729,12274,24237,696266,479348,101095155,507749,100065952
    Gene Symbol and SynonymsC6
    Uniprot AccessionP13671,Q811M5,Q29RU4
    Uniprot Entry NameCO6_HUMAN,CO6_RAT,CO6_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000039537
    Target ClassificationN/A

    The target: C6, gene name: C6, also named as . This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.