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Anti-CO8A/ C8A monoclonal antibody
Anti-CO8A/ C8A antibody for FACS & in-vivo assay
Go to C8A/C8A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2423-Ab-1/ GM-Tg-hg-MP2423-Ab-2 | Anti-Human C8A monoclonal antibody | Human |
| GM-Tg-rg-MP2423-Ab-1/ GM-Tg-rg-MP2423-Ab-2 | Anti-Rat C8A monoclonal antibody | Rat |
| GM-Tg-mg-MP2423-Ab-1/ GM-Tg-mg-MP2423-Ab-2 | Anti-Mouse C8A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2423-Ab-1/ GM-Tg-cynog-MP2423-Ab-2 | Anti-Cynomolgus/ Rhesus macaque C8A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2423-Ab-1/ GM-Tg-felg-MP2423-Ab-2 | Anti-Feline C8A monoclonal antibody | Feline |
| GM-Tg-cang-MP2423-Ab-1/ GM-Tg-cang-MP2423-Ab-2 | Anti-Canine C8A monoclonal antibody | Canine |
| GM-Tg-bovg-MP2423-Ab-1/ GM-Tg-bovg-MP2423-Ab-2 | Anti-Bovine C8A monoclonal antibody | Bovine |
| GM-Tg-equg-MP2423-Ab-1/ GM-Tg-equg-MP2423-Ab-2 | Anti-Equine C8A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2423-Ab-1/ GM-Tg-hg-MP2423-Ab-2; GM-Tg-rg-MP2423-Ab-1/ GM-Tg-rg-MP2423-Ab-2; GM-Tg-mg-MP2423-Ab-1/ GM-Tg-mg-MP2423-Ab-2; GM-Tg-cynog-MP2423-Ab-1/ GM-Tg-cynog-MP2423-Ab-2; GM-Tg-felg-MP2423-Ab-1/ GM-Tg-felg-MP2423-Ab-2; GM-Tg-cang-MP2423-Ab-1/ GM-Tg-cang-MP2423-Ab-2; GM-Tg-bovg-MP2423-Ab-1/ GM-Tg-bovg-MP2423-Ab-2; GM-Tg-equg-MP2423-Ab-1/ GM-Tg-equg-MP2423-Ab-2 |
| Products Name | Anti-C8A monoclonal antibody |
| Format | mab |
| Target Name | C8A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-C8A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CO8A/ C8A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002705 | mouse C8a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002705 | mouse C8a Lentivirus particle |
Target information
| Target ID | GM-MP2423 |
| Target Name | C8A |
| Gene ID | 731,230558,298288,716114,100855712,101096500,527391,100059461 |
| Gene Symbol and Synonyms | C8A |
| Uniprot Accession | P07357 |
| Uniprot Entry Name | CO8A_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000157131 |
| Target Classification | N/A |
The target: C8A, gene name: C8A, also named as . C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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