Anti-CO8G/ C8G/ C8C monoclonal antibody

Anti-CO8G/ C8G/ C8C antibody for FACS & in-vivo assay

Target products collectionGo to C8G/C8G products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2424-Ab-1/ GM-Tg-hg-MP2424-Ab-2Anti-Human C8G monoclonal antibodyHuman
GM-Tg-rg-MP2424-Ab-1/ GM-Tg-rg-MP2424-Ab-2Anti-Rat C8G monoclonal antibodyRat
GM-Tg-mg-MP2424-Ab-1/ GM-Tg-mg-MP2424-Ab-2Anti-Mouse C8G monoclonal antibodyMouse
GM-Tg-cynog-MP2424-Ab-1/ GM-Tg-cynog-MP2424-Ab-2Anti-Cynomolgus/ Rhesus macaque C8G monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2424-Ab-1/ GM-Tg-felg-MP2424-Ab-2Anti-Feline C8G monoclonal antibodyFeline
GM-Tg-cang-MP2424-Ab-1/ GM-Tg-cang-MP2424-Ab-2Anti-Canine C8G monoclonal antibodyCanine
GM-Tg-bovg-MP2424-Ab-1/ GM-Tg-bovg-MP2424-Ab-2Anti-Bovine C8G monoclonal antibodyBovine
GM-Tg-equg-MP2424-Ab-1/ GM-Tg-equg-MP2424-Ab-2Anti-Equine C8G monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2424-Ab-1/ GM-Tg-hg-MP2424-Ab-2; GM-Tg-rg-MP2424-Ab-1/ GM-Tg-rg-MP2424-Ab-2;
GM-Tg-mg-MP2424-Ab-1/ GM-Tg-mg-MP2424-Ab-2; GM-Tg-cynog-MP2424-Ab-1/ GM-Tg-cynog-MP2424-Ab-2;
GM-Tg-felg-MP2424-Ab-1/ GM-Tg-felg-MP2424-Ab-2; GM-Tg-cang-MP2424-Ab-1/ GM-Tg-cang-MP2424-Ab-2;
GM-Tg-bovg-MP2424-Ab-1/ GM-Tg-bovg-MP2424-Ab-2; GM-Tg-equg-MP2424-Ab-1/ GM-Tg-equg-MP2424-Ab-2
Products NameAnti-C8G monoclonal antibody
Formatmab
Target NameC8G
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-C8G benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CO8G/ C8G/ C8C VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2424
    Target NameC8G
    Gene ID733,69379,296545,721647,480672,101098834,517356,100147492
    Gene Symbol and SynonymsC8C,C8G
    Uniprot AccessionP07360
    Uniprot Entry NameCO8G_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000176919
    Target ClassificationN/A

    The target: C8G, gene name: C8G, also named as C8C. The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.