Anti-SUPYN/ ERVH48-1/ C21orf105 monoclonal antibody

Anti-SUPYN/ ERVH48-1/ C21orf105 antibody for FACS & in-vivo assay

Target products collectionGo to ERVH48-1/ERVH48-1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2433-Ab-1/ GM-Tg-hg-MP2433-Ab-2Anti-Human ERVH48-1 monoclonal antibodyHuman
GM-Tg-rg-MP2433-Ab-1/ GM-Tg-rg-MP2433-Ab-2Anti-Rat ERVH48-1 monoclonal antibodyRat
GM-Tg-mg-MP2433-Ab-1/ GM-Tg-mg-MP2433-Ab-2Anti-Mouse ERVH48-1 monoclonal antibodyMouse
GM-Tg-cynog-MP2433-Ab-1/ GM-Tg-cynog-MP2433-Ab-2Anti-Cynomolgus/ Rhesus macaque ERVH48-1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2433-Ab-1/ GM-Tg-felg-MP2433-Ab-2Anti-Feline ERVH48-1 monoclonal antibodyFeline
GM-Tg-cang-MP2433-Ab-1/ GM-Tg-cang-MP2433-Ab-2Anti-Canine ERVH48-1 monoclonal antibodyCanine
GM-Tg-bovg-MP2433-Ab-1/ GM-Tg-bovg-MP2433-Ab-2Anti-Bovine ERVH48-1 monoclonal antibodyBovine
GM-Tg-equg-MP2433-Ab-1/ GM-Tg-equg-MP2433-Ab-2Anti-Equine ERVH48-1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2433-Ab-1/ GM-Tg-hg-MP2433-Ab-2; GM-Tg-rg-MP2433-Ab-1/ GM-Tg-rg-MP2433-Ab-2;
GM-Tg-mg-MP2433-Ab-1/ GM-Tg-mg-MP2433-Ab-2; GM-Tg-cynog-MP2433-Ab-1/ GM-Tg-cynog-MP2433-Ab-2;
GM-Tg-felg-MP2433-Ab-1/ GM-Tg-felg-MP2433-Ab-2; GM-Tg-cang-MP2433-Ab-1/ GM-Tg-cang-MP2433-Ab-2;
GM-Tg-bovg-MP2433-Ab-1/ GM-Tg-bovg-MP2433-Ab-2; GM-Tg-equg-MP2433-Ab-1/ GM-Tg-equg-MP2433-Ab-2
Products NameAnti-ERVH48-1 monoclonal antibody
Formatmab
Target NameERVH48-1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ERVH48-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SUPYN/ ERVH48-1/ C21orf105 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2433
    Target NameERVH48-1
    Gene ID90625,106997228
    Gene Symbol and SynonymsC21orf105,ERVH48-1,NDUFV3-AS1,SUPYN
    Uniprot AccessionM5A8F1
    Uniprot Entry NameSUPYN_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000233056
    Target ClassificationN/A

    The target: ERVH48-1, gene name: ERVH48-1, also named as C21orf105, NDUFV3-AS1. Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015].



    About Gmab

    GDU
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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.