Anti-HPSE2/ HPA2/ HPR2 monoclonal antibody

Anti-HPSE2/ HPA2/ HPR2 antibody for FACS & in-vivo assay

Target products collectionGo to HPSE2/HPSE2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2434-Ab-1/ GM-Tg-hg-MP2434-Ab-2Anti-Human HPSE2 monoclonal antibodyHuman
GM-Tg-rg-MP2434-Ab-1/ GM-Tg-rg-MP2434-Ab-2Anti-Rat HPSE2 monoclonal antibodyRat
GM-Tg-mg-MP2434-Ab-1/ GM-Tg-mg-MP2434-Ab-2Anti-Mouse HPSE2 monoclonal antibodyMouse
GM-Tg-cynog-MP2434-Ab-1/ GM-Tg-cynog-MP2434-Ab-2Anti-Cynomolgus/ Rhesus macaque HPSE2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2434-Ab-1/ GM-Tg-felg-MP2434-Ab-2Anti-Feline HPSE2 monoclonal antibodyFeline
GM-Tg-cang-MP2434-Ab-1/ GM-Tg-cang-MP2434-Ab-2Anti-Canine HPSE2 monoclonal antibodyCanine
GM-Tg-bovg-MP2434-Ab-1/ GM-Tg-bovg-MP2434-Ab-2Anti-Bovine HPSE2 monoclonal antibodyBovine
GM-Tg-equg-MP2434-Ab-1/ GM-Tg-equg-MP2434-Ab-2Anti-Equine HPSE2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2434-Ab-1/ GM-Tg-hg-MP2434-Ab-2; GM-Tg-rg-MP2434-Ab-1/ GM-Tg-rg-MP2434-Ab-2;
GM-Tg-mg-MP2434-Ab-1/ GM-Tg-mg-MP2434-Ab-2; GM-Tg-cynog-MP2434-Ab-1/ GM-Tg-cynog-MP2434-Ab-2;
GM-Tg-felg-MP2434-Ab-1/ GM-Tg-felg-MP2434-Ab-2; GM-Tg-cang-MP2434-Ab-1/ GM-Tg-cang-MP2434-Ab-2;
GM-Tg-bovg-MP2434-Ab-1/ GM-Tg-bovg-MP2434-Ab-2; GM-Tg-equg-MP2434-Ab-1/ GM-Tg-equg-MP2434-Ab-2
Products NameAnti-HPSE2 monoclonal antibody
Formatmab
Target NameHPSE2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HPSE2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HPSE2/ HPA2/ HPR2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2434
    Target NameHPSE2
    Gene ID60495,545291,368128,708795,486831,101083879,537343,100070602
    Gene Symbol and SynonymsGm968,HPA2,HPR2,HPSE2,UFS,UFS1
    Uniprot AccessionQ8WWQ2
    Uniprot Entry NameHPSE2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000172987
    Target ClassificationN/A

    The target: HPSE2, gene name: HPSE2, also named as HPA2, HPR2, UFS, UFS1. This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.