- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-HRG/ HPRGP/ THPH11 monoclonal antibody
Anti-HRG/ HPRGP/ THPH11 antibody for FACS & in-vivo assay
Go to HRG/HRG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2435-Ab-1/ GM-Tg-hg-MP2435-Ab-2 | Anti-Human HRG monoclonal antibody | Human |
| GM-Tg-rg-MP2435-Ab-1/ GM-Tg-rg-MP2435-Ab-2 | Anti-Rat HRG monoclonal antibody | Rat |
| GM-Tg-mg-MP2435-Ab-1/ GM-Tg-mg-MP2435-Ab-2 | Anti-Mouse HRG monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2435-Ab-1/ GM-Tg-cynog-MP2435-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HRG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2435-Ab-1/ GM-Tg-felg-MP2435-Ab-2 | Anti-Feline HRG monoclonal antibody | Feline |
| GM-Tg-cang-MP2435-Ab-1/ GM-Tg-cang-MP2435-Ab-2 | Anti-Canine HRG monoclonal antibody | Canine |
| GM-Tg-bovg-MP2435-Ab-1/ GM-Tg-bovg-MP2435-Ab-2 | Anti-Bovine HRG monoclonal antibody | Bovine |
| GM-Tg-equg-MP2435-Ab-1/ GM-Tg-equg-MP2435-Ab-2 | Anti-Equine HRG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2435-Ab-1/ GM-Tg-hg-MP2435-Ab-2; GM-Tg-rg-MP2435-Ab-1/ GM-Tg-rg-MP2435-Ab-2; GM-Tg-mg-MP2435-Ab-1/ GM-Tg-mg-MP2435-Ab-2; GM-Tg-cynog-MP2435-Ab-1/ GM-Tg-cynog-MP2435-Ab-2; GM-Tg-felg-MP2435-Ab-1/ GM-Tg-felg-MP2435-Ab-2; GM-Tg-cang-MP2435-Ab-1/ GM-Tg-cang-MP2435-Ab-2; GM-Tg-bovg-MP2435-Ab-1/ GM-Tg-bovg-MP2435-Ab-2; GM-Tg-equg-MP2435-Ab-1/ GM-Tg-equg-MP2435-Ab-2 |
| Products Name | Anti-HRG monoclonal antibody |
| Format | mab |
| Target Name | HRG |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HRG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HRG/ HPRGP/ THPH11 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2435 |
| Target Name | HRG |
| Gene ID | 3273,94175,171016,699100,100683193,101082002,280820,100068112 |
| Gene Symbol and Synonyms | D16jh2,D18020,HPRG,HRG,HRG1,HRGP,THPH11 |
| Uniprot Accession | P04196,Q99PS8,P33433 |
| Uniprot Entry Name | HRG_HUMAN,HRG_RAT,HRG_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000113905 |
| Target Classification | N/A |
The target: HRG, gene name: HRG, also named as HPRGP, THPH11, HRG. This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
