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Anti-HYAL3/ HYAL-3/ LUCA-3 monoclonal antibody
Anti-HYAL3/ HYAL-3/ LUCA-3 antibody for FACS & in-vivo assay
Go to HYAL3/HYAL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2436-Ab-1/ GM-Tg-hg-MP2436-Ab-2 | Anti-Human HYAL3 monoclonal antibody | Human |
| GM-Tg-rg-MP2436-Ab-1/ GM-Tg-rg-MP2436-Ab-2 | Anti-Rat HYAL3 monoclonal antibody | Rat |
| GM-Tg-mg-MP2436-Ab-1/ GM-Tg-mg-MP2436-Ab-2 | Anti-Mouse HYAL3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2436-Ab-1/ GM-Tg-cynog-MP2436-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HYAL3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2436-Ab-1/ GM-Tg-felg-MP2436-Ab-2 | Anti-Feline HYAL3 monoclonal antibody | Feline |
| GM-Tg-cang-MP2436-Ab-1/ GM-Tg-cang-MP2436-Ab-2 | Anti-Canine HYAL3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2436-Ab-1/ GM-Tg-bovg-MP2436-Ab-2 | Anti-Bovine HYAL3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2436-Ab-1/ GM-Tg-equg-MP2436-Ab-2 | Anti-Equine HYAL3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2436-Ab-1/ GM-Tg-hg-MP2436-Ab-2; GM-Tg-rg-MP2436-Ab-1/ GM-Tg-rg-MP2436-Ab-2; GM-Tg-mg-MP2436-Ab-1/ GM-Tg-mg-MP2436-Ab-2; GM-Tg-cynog-MP2436-Ab-1/ GM-Tg-cynog-MP2436-Ab-2; GM-Tg-felg-MP2436-Ab-1/ GM-Tg-felg-MP2436-Ab-2; GM-Tg-cang-MP2436-Ab-1/ GM-Tg-cang-MP2436-Ab-2; GM-Tg-bovg-MP2436-Ab-1/ GM-Tg-bovg-MP2436-Ab-2; GM-Tg-equg-MP2436-Ab-1/ GM-Tg-equg-MP2436-Ab-2 |
| Products Name | Anti-HYAL3 monoclonal antibody |
| Format | mab |
| Target Name | HYAL3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HYAL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HYAL3/ HYAL-3/ LUCA-3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005130 | mouse Hyal3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005130 | mouse Hyal3 Lentivirus particle |
Target information
| Target ID | GM-MP2436 |
| Target Name | HYAL3 |
| Gene ID | 8372,109685,300993,106996913,608620,101092920,616562,100061939 |
| Gene Symbol and Synonyms | HYAL-3,HYAL3,Hyl3,LUCA-3,LUCA3 |
| Uniprot Accession | O43820,Q76HM9 |
| Uniprot Entry Name | HYAL3_HUMAN,HYAL3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000186792 |
| Target Classification | N/A |
The target: HYAL3, gene name: HYAL3, also named as HYAL-3, LUCA-3, LUCA3. This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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